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Embelin Mitigates Amyloid-β-Induced Neurotoxicity and Cognitive Impairment in Rats: Potential Therapeutic Implications for Alzheimer’s Disease
Alzheimer’s disease (AD) is a significant form of dementia. Embelin (EMB) is a natural compound with varied actions that could help prevent AD...
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Moving from idea to reality: The barriers and enablers to implementing Child and Family Hubs policy into practice in NSW, Australia
BackgroundAdverse childhood experiences can impact physical and mental health throughout the lifespan. To support families experiencing adversity and...
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Mavorixafor: First Approval
Mavorixafor (XOLREMDI™) is an oral, selective C-X-C chemokine receptor 4 (CXCR4) antagonist developed by X4 Pharmaceuticals that blocks the binding...
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TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers
BackgroundDetection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...
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Impact of acid and laser etching of enamel on microleakage in different adhesive systems
This study aimed to evaluate the microleakage of light-cured and self-cured adhesives on enamel surfaces selectively etched with Er, Cr: YSGG laser...
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Prognostic value of serum high-mobility group box 1 in neonates with neonatal encephalopathy
BackgroundThis study aimed to investigate the diagnostic potential of serum high-mobility group box 1 (HMGB1) in neonatal encephalopathy (NE).
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Genetic neurodevelopmental clustering and dyslexia
Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading and spelling. It is...
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Building bridges: evaluating policymakers' research capacities, engagement, and utilization in health policymaking within the Kuwaiti context: a cross-sectional study
BackgroundHealth policymaking is a critical aspect of governmental decision-making that shapes the well-being of populations. In the Middle East and...
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Code- and Meaning-related Emergent Literacy Skills and Joint Attention in Autistic and Non-Autistic Children
Code- and meaning-related emergent literacy skills of autistic children were compared to those of non-autistic children who did not differ on age and...
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Association of ambient temperature on acute ischemic stroke in Yancheng, China
BackgroundAcute ischemic stroke (AIS) is a major global public health issue. There is limited research on the relationship between ambient...
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Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience
BackgroundAdvanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...
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Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel
The voltage-dependent potassium channels (Kv channels) show several different types of inactivation. N-type inactivation is a fast inactivating...
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A Short Game-Based Intervention for Enhancing Executive Functions at School: a Pilot Study
Executive functions (EFs) are crucial for self-regulation, and they can explain the difficulties that many children face at school in terms of both...
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Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders
Psychiatric disorders such as Bipolar disorder, Anxiety, Major depressive disorder, Schizophrenia, Attention-deficit/hyperactivity disorder, as well...
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Mechanisms involved in the antidepressant-like action of orally administered 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) in male and female mice
RationaleThe compound 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) has recently been shown to inhibit in vitro acetylcholinesterase...
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