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Does platelet transfusion threshold in premature infants impact neurodevelopmental outcomes?

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Fig. 1: Illustration of the impact of dichotomization.

References

  1. Moore CM, D’Amore A, Fustolo-Gunnink S, Hudson C, Newton A, Santamaria BL, et al. Two-year outcomes following a randomised platelet transfusion trial in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2023;108:452–7.

    PubMed  Google Scholar 

  2. Curley A, Stanworth SJ, Willoughby K, Fustolo-Gunnink SF, Venkatesh V, Hudson C, et al. Randomized Trial of Platelet-Transfusion Thresholds in Neonates. N. Engl J Med. 2019;380:242–51.

    Article  CAS  PubMed  Google Scholar 

  3. McFadyen JD, Kaplan ZS. Platelets are not just for clots. Transfus Med Rev. 2015;29:110–9.

    Article  PubMed  Google Scholar 

  4. Davenport P, Sola-Visner M. Platelets in the neonate: not just a small adult. Res Pr Thromb Haemost. 2022;6:e12719.

    Article  CAS  Google Scholar 

  5. Piccirilli E, Chiarelli AM, Sestieri C, Mascali D, Calvo Garcia D, Primavera A, et al. Cerebral blood flow patterns in preterm and term neonates assessed with pseudo-continuous arterial spin labeling perfusion MRI. Hum Brain Mapp. 2023;44:3833–44.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Maitre NL, Marshall DD, Price WA, Slaughter JC, O’Shea TM, Maxfield C, et al. Neurodevelopmental outcome of infants with unilateral or bilateral periventricular hemorrhagic infarction. Pediatrics. 2009;124:e1153–60.

    Article  PubMed  Google Scholar 

  7. Altman DG, Royston P. The cost of dichotomising continuous variables. BMJ. 2006;332:1080.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Royston P, Altman DG, Sauerbrei W. Dichotomizing continuous predictors in multiple regression: a bad idea. Stat Med. 2006;25:127–41.

    Article  PubMed  Google Scholar 

  9. Streiner DL. Breaking up is hard to do: the heartbreak of dichotomizing continuous data. Can J Psychiatry. 2002;47:262–6.

    Article  PubMed  Google Scholar 

  10. van Walraven C, Hart RG. Leave ‘em alone - why continuous variables should be analyzed as such. Neuroepidemiology. 2008;30:138–9.

    Article  PubMed  Google Scholar 

  11. MacCallum RC, Zhang S, Preacher KJ, Rucker DD. On the practice of dichotomization of quantitative variables. Psychol Methods. 2002;7:19–40.

    Article  PubMed  Google Scholar 

  12. Naggara O, Raymond J, Guilbert F, Roy D, Weill A, Altman DG. Analysis by categorizing or dichotomizing continuous variables is inadvisable: an example from the natural history of unruptured aneurysms. AJNR Am J Neuroradiol. 2011;32:437–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. McClelland GH, Lynch J, John G, Irwin JR, Spiller SA, Fitzsimons GJ. Median splits, Type II errors, and false–positive consumer psychology: Don’t fight the power. J Consum Psychol. 2015;25:679–89.

    Article  Google Scholar 

  14. Haslam MD, Lisonkova S, Creighton D, Church P, Yang J, Shah PS, et al. Severe neurodevelopmental impairment in neonates born preterm: impact of varying definitions in a Canadian cohort. J Pediatr. 2018;197:75–81.e4.

    Article  PubMed  Google Scholar 

  15. Selvin S. Statistical Power and Sample Size Calculations: Statistical Analysis of Epidemiologic Data. 3rd ed: Oxford University Press; 2004.

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Acknowledgements

The Journal Club is a collaboration between the American Academy of Pediatrics - Section of Neonatal Perinatal Medicine and the International Society for Evidence-Based Neonatology (EBNEO.org).

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Authors and Affiliations

  1. Division of Neonatal-Perinatal Medicine, Penn State Health Children’s Hospital, Hershey, PA, USA

    Nada Darwish, Kristen Glass & Tammy E. Corr

  2. Penn State College of Medicine, Department of Pediatrics, Hershey, PA, USA

    Kristen Glass & Tammy E. Corr

Authors
  1. Nada Darwish
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  2. Kristen Glass
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  3. Tammy E. Corr
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Contributions

ND devised the concept of the paper, drafted the initial manuscript, created the figures, reviewed and revised the manuscript, and prepared it for publication. KG contributed to the concept of the paper and critically reviewed and revised the manuscript. TC contributed to the concept of the paper, and was involved in writing, critically reviewing and revising the manuscript. All authors approved the final manuscript as submitted, agree to be accountable for all aspects of the work, and attest to the accuracy and integrity of the work presented here.

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Correspondence to Nada Darwish.

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The authors declare no competing interests.

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Darwish, N., Glass, K. & Corr, T.E. Does platelet transfusion threshold in premature infants impact neurodevelopmental outcomes?. J Perinatol (2024). https://doi.org/10.1038/s41372-024-02056-5

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  • DOI: https://doi.org/10.1038/s41372-024-02056-5

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