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The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
Proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol metabolism and cardiovascular diseases, has recently...
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Epidemiology, outcomes and prognosis of infective endocarditis in Northern Morocco
IntroductionInfective endocarditis is a rare but potentially severe disease, associated with significant morbidity and mortality. Our study aims to...
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Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience
BackgroundAdvanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...
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Estimated Incidence of Hospitalizations Attributable to RSV Infection Among Adults in Ontario, Canada, Between 2013 and 2019
IntroductionAdult respiratory syncytial virus (RSV) burden is underestimated due to non-specific symptoms, limited standard-of-care and delayed...
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FADD regulates adipose inflammation, adipogenesis, and adipocyte survival
Adipose tissue, aside from adipocytes, comprises various abundant immune cells. The accumulation of low-grade chronic inflammation in adipose tissue...
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Development of a novel approach for restoration of the meniscus using silk-elastin in a rabbit meniscus injury model
BackgroundLimited healing potential of the meniscus remains a burden for the successful repair of meniscus injuries in the orthopaedic fields....
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Changes in the anteroposterior position of the femur relative to the tibia impact patient satisfaction in total knee arthroplasty
BackgroundIn this study, we aimed to investigate the preoperative and postoperative anteroposterior position (AP) of the femur relative to the tibia...
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Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study
BackgroundAnticholinergic medications are now widely acknowledged for their unfavorable risk-to-benefit profile owing to their adverse effects....
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Single center assessment of the role of Oakland score among patients admitted for acute lower gastrointestinal bleeding
Background/ObjectivesThe Oakland score was developed to predict safe discharge in patients who present to the emergency department with lower...
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Anti-C5 monoclonal antibody treatment showing pathological resolution of complement-mediated atypical hemolytic uremic syndrome: a case report
BackgroundNo reports have shown histological changes before and after anti-C5 monoclonal antibody treatment in patients with atypical hemolytic...
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Time to recovery and predictors among admitted preterm neonates in the neonatal intensive care units of public hospitals of Addis Ababa, Ethiopia, 2021
IntroductionEthiopia implemented measures to reduce preterm mortality, and much is currently being done to avoid preterm death, yet preterm death...
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Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis
Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression...
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Evaluation of the effect of trendelenburg position duration on intracranial pressure in laparoscopic hysterectomies using ultrasonographic optic nerve sheath diameter measurements
BackgroundDuring laparoscopic surgery, pneumoperitoneum and Trendelenburg positioning applied to provide better surgical vision can cause many...
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ISIS 449884 Injection Add-On to Metformin in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase II Clinical Study
IntroductionISIS 449884, a 2′- O -methoxyethyl antisense oligonucleotide that targets the glucagon receptor (GCGR), has demonstrated an ability to...
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The impact of codeine rescheduling on non-opioid analgesic use by people who regularly use codeine: a prospective cohort study
BackgroundCodeine was rescheduled in Australia to prescription only in February 2018. Initial studies reported an increase in population level...
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Impact of medicine shortages on hospital practice: role of a multidisciplinary medicine shortages team
Medicine shortages are an increasing issue, with broad public health implications for patients, health professionals and institutions. Despite...
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