Search
Search Results
-
Synthesis and evaluation of pyridine-3-carboxamide analogs as effective agents against bacterial wilt in tomatoes
This study focused on develo** novel pyridine-3-carboxamide analogs to treat bacterial wilt in tomatoes caused by Ralstonia solanacearum . The...
-
Pyrazole-sulfonamide scaffold featuring dual-tail strategy as apoptosis inducers in colon cancer
Dual-tail strategy has been successfully utilized in the development of novel carbonic anhydrase IX (CA IX) inhibitors. Herein we adopted this...
-
Direct coupling of CO2 with epoxides catalyzed by lanthanum(III) supported on magnetic mesoporous organosilica nanoparticles
Lanthanum(III) supported on the magnetic mesoporous organosilica nanoparticle (La@MON) has been described as an efficient, simple, and durable...
-
Anticancer evaluation and molecular docking of new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives
3-Amino-4,6-dimethylpyrazolopyridine was applied as a precursor for the synthesis of some new pyridopyrazolo-triazine and pyridopyrazolo-triazole...
-
Quantitative structure-activity relationship (QSAR) modelling study of some novel carboxamide series as new anti-tubercular agents
BackgroundQSAR modelling was performed on thirty-five (35) newly discovered compounds of N-(2-phenoxy) ethyl imidazo[1,2-a] pyridine-3-carboxamide...
-
Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening
We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000...
-
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
A very practical method for the synthesis of unsymmetrical carbamide derivatives in good to excellent yield was presented, without the need for any...
-
Screening of microalgae liquid extracts for their bio stimulant properties on plant growth, nutrient uptake and metabolite profile of Solanum lycopersicum L.
The present study investigates the biostimulant effects of 18 Crude Bio-Extracts (CBEs) obtained from Microalgae and Cyanobacteria on tomato plant...
-
Crystal structure of [1,2,4]triazolo[4,3-
b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship studyBRD4 contains two tandem bromodomains (BD1 and BD2) that recognize acetylated lysine for epigenetic reading, and these bromodomains are promising...
-
Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation
Multitarget anticancer drugs are more superior than single target drugs regarding patient compliance, drug adverse effects, drug-drug interactions,...
-
Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies
In this strategy, we attempt to design various novel nitrogen-rich heterocycles in one molecule. Green, simple, and efficient aza-annulations of an...
-
The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease
Dysregulation of nicotinamide adenine dinucleotide (NAD +) metabolism contributes to the initiation and progression of age-associated diseases,...
-
Cobalt-catalyzed branched selective hydroallylation of terminal alkynes
Here, we reported a cobalt-hydride-catalyzed Markovnikov-type hydroallylation of terminal alkynes with allylic electrophile to access valuable and...
-
Novel psoralen derivatives as anti-breast cancer agents and their light-activated cytotoxicity against HER2 positive breast cancer cells
Psoralen derivatives are well known for their unique phototoxicity and also exhibits promising anti-breast cancer activity both in the presence and...
-
Molecular dynamics and in silico mutagenesis on the reversible inhibitor-bound SARS-CoV-2 main protease complexes reveal the role of lateral pocket in enhancing the ligand affinity
The 2019 novel coronavirus pandemic caused by SARS-CoV-2 remains a serious health threat to humans and there is an urgent need to develop...
-
Conventional and synchronous spectrofluorometric determination of the recently administered drugs for treatment of COVID-19 favipiravir and apixaban
COVID-19 is a fast-spreading pandemic that is caused by SARS-CoV-2 viral pathogen. Combination therapy of the antiviral favipiravir and the...
-
Antiplasmodial activity, structure–activity relationship and studies on the action of novel benzimidazole derivatives
Malaria cases and deaths keep being excessively high every year. Some inroads gained in the last two decades have been eroded especially due to the...
-
Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility
Based on the pharmaceutical potentials of coumarins, which have antitumor activity, we synthesized new coumarin derivatives and evaluated their...
-
Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition
Hydrogen sulfide (H 2 S) is a gaseous signaling molecule that participates in various signaling functions in health and diseases. The tetrameric...
-
Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines
Chiral amines are commonly used in the pharmaceutical and agrochemical industries
1 . The strong demand for unnatural chiral amines has driven the...