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Using Polysorbates to Create Parenteral Dosage Forms of Hydrophobic Substances (A Review)
Low solubility of drugs is a constantly encountered problem for pharmaceutical science in the field of parenteral dosage form development. This...
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Development of the Composition and Technology for Obtaining a Model of an Injection Form of an Indolocarbazole Derivative
The indolocarbazole derivative LCS-1269 has a multitarget mechanism of action on tumors and blocks vasculogenic mimicry. The hydrophobic character of...
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Formulation and Evaluation of Tamarind Seed Polysaccharide Gel for the Controlled Delivery of Aceclofenac
The purpose of this study was to develop a transdermal gel with the addition of different polymer ratios that incorporates 1.0 %w/w aceclofenac to...
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Quality by Design (QbD) Process Design
Quality by design (QbD) principles have become widely adopted in the pharmaceutical industry to ensure consistent quality of products through their...
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In vitro anticancer evaluation of micelles containing N-(4-(2-((4-methoxybenzyl)amino)ethyl)phenyl)heptanamide, an analogue of fingolimod
Fingolimod has been evaluated for use as an anticancer agent. However, many steps are required to synthesize fingolimod because of its intricate...
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Bridging the Gap: A Comparative Investigation of Pharmaceutical Excipient Regulations
Since the awareness of adverse effects associated with pharmaceutical excipients in drug formulations, these excipients are no longer considered...
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Influence of Water-Soluble Pharmaceutically Acceptable Polymers on the Solubility of Darunavir and Darunavir Ethanolate
The solubility of darunavir (D) and darunavir ethanolate (DE) at physiological pH values and temperatures in solutions of pharmaceutically acceptable...
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Using Liposomal and Intranasal Drugs and Pioglitazone for the Treatment and Prevention of Alzheimer’s Disease (Review)
This review article provides information on the development of liposomal drug delivery systems to cross the blood(brain barrier (BBB). Information on...
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Pharmacological Activities and Pharmacokinetics of Glycycoumarin
Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from Glycyrrhiza uralensis Fisch., Fabaceae....
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Synthesis of a Disulfuram Inclusion Complex with Hydroxypropyl-β-Cyclodextrin and Its Effect on Cataract Development in Rats
Formation of inclusion complexes from disulfiram and hydroxypropyl-β-cyclodextrin was confirmed using x-ray diffraction, differential scanning...
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Chemical Enhancers or Transcutaneous Conductors: Transcutol
The concept of enhancers or transcutaneous conductors and their classification and mechanism of action are discussed. Special attention is paid to...
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Pharmacopoeial Quality Requirements for Medicinal Products
General approaches to the elaboration of pharmacopoeial quality standards for medicinal products that are based on good pharmacopoeial practice...
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Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Emerging Lipid Based Drug Delivery Systems
In the past decade, research in the area of nanodrug delivery has reached a new height with the advent of lipid based nanodrug delivery systems....
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Efficacy of an Intravenous Form of Rifapentine in a Model of Experimental Tuberculosis in Mice
Solubilization of rifapentine with human serum albumin (HSA) was used to produce a water-miscible form consisting of a colloidal suspension of...
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Optimization of Astaxanthin microencapsulation in hydrophilic carriers using response surface methodology
Astaxanthin (3, 3′-dihydroxy-β, β-carotene-4, 4′-dione; AST) belongs to class of xanthophylls and is very effective antioxidant. It has very poor...
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Effect of magnesium carbonate on the solubility, dissolution and oral bioavailability of fenofibric acid powder as an alkalising solubilizer
To investigate the possibility of develo** a novel oral pharmaceutical product using fenofibric acid instead of choline fenofibrate, the powder...
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Solutions: Characteristics, Classification, and Basic Quality Requirements
Solutions containing pharmaceuticals of various origins are one of the most popular dosage forms. Pharmaceuticals for parenteral, ophthalmic,...
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Alteration of electroosmotic volume flow through skin by polyethylene glycols
We have studied the effect of polyethylene glycols (PEGs) on the iontophoretic flux of acetaminophen (AAP) using conventional in vitro iontophoresis...
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Solubilization of Hydrophobic Antitumor Drugs (Review)
Advances in chemotherapy always depend on the physician’s correct selection of a medicinal formulation in which the main active ingredient or complex...
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Properties of the Novel Photosensitizer β,β,β′,β′-Tetramethyltribenzotetraazachlorin
The abilities of solubilizers Cremophor EL, Tween 80, Emuxol 3, and Pluronic F-68 to deliver the novel promising photosensitizer...
