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IN SILICO and IN VITRO Estimation of MAO-B Inhibitory Activity of Newly Synthesized Hydrazones Bearing a Pyrrole Heterocyclic System
This paper is focused on the in silico and in vitro determination of MAO-B inhibitory activity on recombinant MAO-B enzyme ( h MAOB) of newly...
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Antioxidant Properties, Neuroprotective Effects and in Vitro Safety Evaluation of New Pyrrole Derivatives
The paper is focused on safety evaluation, antioxidant activity and neuroprotective properties determination of newly synthesized substituted...
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Fluorinated pyrrole incorporated 2-thiazolyl hydrazone motifs: a new class of antimicrobial and anti tuberculosis agents
In aim of obtaining novel bio-active compounds, a new series of fluorinated 1-(4-(aryl)thiazol-2-yl)-2-((1-(aryl)-2,5-dimethyl-1 H -pyrrol-3-yl)methylen...
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Synthesis and Cytotoxic Activity of Ethyl 2-Amino-1-Benzamido-4-Oxo-5-(2-Oxo-2-Arylethylidene)- 4,5-Dihydro-1H-Pyrrole-3-Carboxylates
Recyclization of 5-aryl-2,3-dihydro-2-furandione 3-benzoylhydrazones ( I ) induced by cyanoacetic ester produced ethyl...
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Synthesis and Antibacterial Activity of 3-Pyrrol-1-Ylthieno[2,3-b ]Pyridine-2-Carboxylic Acid [(Phenyl-,1,3-Benzodioxol-5-YL)Methylene]Hydrazides
Aseries of 3-pyrrol-1-ylthieno[3,2- b ]pyridine-2-carboxylic acid [(phenyl-, 1,3-benzodioxol-5-yl)methylene]- hydrazides were synthesized by reacting...
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Synthesis of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones as potential antimicrobial agents
Synthesis of new derivatives of pyrido[2,3- d ][1,2,4]triazolo[4,3- a ]pyrimidin-5-one via reaction of...
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Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity
Isatin, k1H-indole-2,3-dione, kis a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule,...
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Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice
Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of...
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Antimicrobial activity of a new series of benzimidazole derivatives
Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazolehydrazone compounds were synthesized to screen their...
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Synthesis and antimicrobial activity of a number of pyrroloindole derivatives
A method for the predominant synthesis of linear pyrroloindoles was developed, based on the attachment of the pyrrole ring to indoline and including...
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Carbolines. Part I: Comparison of some methods for the synthesis of α-, γ-, and δ-carbolines (a review)
The main trends in the development of the chemistry of α-, γ-, and δ-carbolines are generalized. Syntheses of carbolines based on pyridine...
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