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Carbolines. Part I: Comparison of some methods for the synthesis of α-, γ-, and δ-carbolines (a review)

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Pharmaceutical Chemistry Journal Aims and scope

The main trends in the development of the chemistry of α-, γ-, and δ-carbolines are generalized. Syntheses of carbolines based on pyridine derivatives (including the Fischer synthesis, Graebe—Ullmann reaction, thermal decomposition of azides, photochemical cyclization of anilinopyridines, arylation of substituted pyridines and piperidones, etc.) and based on indole derivatives are described. Published data about the biological activity of compounds belonging to these series are summarized.

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Notes

  1. Neurodegenerative diseases (degenerative diseases of the nervous system) represent a large group of related diseases caused by massive progressive neuron death. The neurodegenerative process for AD is associated with progressive memory loss and reduced mental and intellectual capacity with subsequent slow progressive dementia.

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Authors and Affiliations

  1. Center for Drug Chemistry, Moscow, Russia

    O. B. Smirnova, T. V. Golovko & V. G. Granik

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  1. O. B. Smirnova
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  2. T. V. Golovko
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  3. V. G. Granik
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 12, pp. 6 – 30, December, 2010.

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Smirnova, O.B., Golovko, T.V. & Granik, V.G. Carbolines. Part I: Comparison of some methods for the synthesis of α-, γ-, and δ-carbolines (a review). Pharm Chem J 44, 654–678 (2011). https://doi.org/10.1007/s11094-011-0540-z

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