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Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract
An attempt to identify the peptide structure of bovine prostate extract using water/vinegar technology followed by tangential ultrafiltration is...
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Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon
A technique for encapsulating the anti-inflammatory dodecapeptide ingramon into microspheres of a biodegradable copolymer of lactic and glycolic...
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Gαi-derived peptide binds the µ-opioid receptor
BackgroundG protein-coupled receptors (GPCRs) transduce external stimuli into the cell by G proteins via an allosteric mechanism. Agonist binding to...
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The Role of the HL-10 Peptide in Regulating the Expression of Apoptosis-Related Genes in the HeLa Cancer Cell Line
Anticancer peptides are among the most important bioactive peptides found in animal sources. The modulation of the molecular process of apoptosis via...
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Brevinin-2R: Antimicrobial Peptide with Cytotoxic and Apoptogenic Activity Against Daunorubicin Resistant Gastric Cancer Cells
Brevinin-2R (B-2R) peptide has been isolated from the skin of Rana ridibunda frog.We have investigated the effects of B-2R on cell viability and...
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Calcitonin gene-related peptide-targeted therapies are effective options for the prevention and treatment of migraine
Calcitonin gene-related peptide (CGRP)-targeted therapies have established efficacy in the treatment of migraine and are generally well tolerated....
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Effect of Tin(II) Chloride Amount on 99mTc-Labeling of One 6-Hydrazinonicotinamide-Conjugated Peptide in the Presence of Tricine/Nicotinic Acid
The use of tin(II) chloride in amount above its required mole ratio as reducing agent can lead to instability of peptide-based radiopharmaceuticals....
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The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease
Diabetes leads to a significantly accelerated incidence of various related macrovascular complications, including peripheral vascular disease and...
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Investigation of the Membranotropic Properties of Acylated Peptide Derivatives of Dopamine and Serotonin Using the Pampa Method
Peptide derivatives of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) acylated with lauric acid (LA) and oleic acid (OA), including...
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Biopharmaka: Peptide, Proteine, Nucleotide und Makrolide als Wirkstoffe
In vielen Kapiteln dieses Buchs ist die Bedeutung von Peptiden, Proteinen, Zuckern oder Nucleotiden für die funktionalen Abläufe in unserem Körper...
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GLUT inhibitor WZB117 induces cytotoxicity with increased production of amyloid-beta peptide in SH-SY5Y cells preventable by beta-hydroxybutyrate: implications in Alzheimer’s disease
BackgroundInhibitors of glucose transporters are being explored as potential anti-cancer drugs. Decreased cerebral glucose utilization with reduced...
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Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression
Depression is a highly prevalent mood disorder and one of the major health concerns in modern society. Moreover, it is characterized by a high...
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Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-coupled receptors. Among them, FPR2 is a low affinity receptor...
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Peptidomimetika
Peptide sind aus Aminosäuren aufgebaute, kettenförmige Moleküle (◘ Abb. 10.1). Ihre Hauptkette besteht aus einer alternierenden Abfolge von...
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Peptide Phage Display: Molecular Principles and Biomedical Applications
Phage display (PD) is a technology based on the presentation of functional exogenous peptides on the capsid surface of bacteriophages. PD is...
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Comparative Evaluation of Alternative Deblocking Agents to Piperidine for Solid-Phase Synthesis of Peptides
The availability of piperidine, which is widely used for deblocking α-amine groups in solid-phase peptide synthesis using Fmoc methodology, is now...
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Isolation and Characterization of a New Antimicrobial Peptide from Pimpinella anisum Seeds
A homogeneous peptide of molecular mass 9.0 kDa with high antimicrobial activity for E. coli ATCC11229 and Candida albicans ATCC10231 was isolated...
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Design and Spectral Validation of RAD51 Inhibitors Based on BRC4 (1523-1546)
RAD51 is a core factor for homologous recombination to repair DNA double-strand breaks and overexpressed in breast cancer cells. Truncated peptide...
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Neuroprotective effect of apelin-13 and other apelin forms—a review
Neurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are...
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Alternative Synthesis of Cobimetinib
A novel approach for synthesis of Cobimetinib was reported, avoiding usage of a strong base in any of the steps with a chiral substrate. An efficient...
