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L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke
BackgroundL-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...
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Neuroprotection through G-CSF: recent advances and future viewpoints
Granulocyte-colony stimulating factor (G-CSF), a member of the cytokine family of hematopoietic growth factors, is 19.6 kDa glycoprotein which is...
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GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders
Movement disorders are neurological conditions characterized by involuntary motor movements, such as dystonia, ataxia, chorea myoclonus, tremors,...
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Neuroprotective Effects of Cannabidiol Under Cerebral Ischemic Conditions
AbstractThe lack of blood flow during cerebral ischemic conditions results in multiple and intricate pathophysiological mechanisms including...
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Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin
Daphnetin is a 7, 8 dihydroxy coumarin isolated from different medicinal plants of the Thymelaeaceae family and exhibits copious pharmacological...
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Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior
Accumulating evidence highlights chemokines as key mediators of the bidirectional crosstalk between neurons and glial cells aimed at preserving brain...
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Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine
Neurodegenerative diseases (NDDs) encompass a range of conditions characterized by the specific dysfunction and continual decline of neurons, glial...
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Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism
Metabolic disturbances in the brain are assumed to be early changes involved in the pathogenesis of depression, and these alterations may be...
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Neuroprotective and Neuroregenerative Properties of Dimeric Dipeptide Mimetics of Individual NGF and BDNF Loops Under Conditions of an Experimental Ischemic Stroke Model
This article reviews our work devoted to studying the biochemical properties of original dimeric dipeptide mimetics of nerve growth factor (NGF) and...
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Anti-amnesic and Neuroprotective Potential of Genistein Against Alzheimer’s Disease
Alzheimer’s disease, the most prevalent neurodegenerative disorder, is characterized by language deficits, impairment of problem-solving ability,...
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Research progress of propofol in alleviating cerebral ischemia/reperfusion injury
Ischemic stroke is a leading cause of adult disability and death worldwide. The primary treatment for cerebral ischemia patients is to restore blood...
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Amelioration of Doxorubicin-Induced Cognitive Impairment by Quercetin in a Rat Model of Breast Cancer
The management of breast cancer by chemotherapeutic agents has significantly increased the survival rates and, at the same time, raised concerns...
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Boswellic Acid Nanoparticles: Promising Strategies for Increasing Therapeutic Effects
Boswellic acids, the main active compound found in the oleo-gum resin of Boswellia serrata Roxb., Burseraceae, have been used in traditional and...
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Exploring the antidepressant-like potential of the selective I2-imidazoline receptor ligand LSL 60101 in adult male rats
BackgroundWhile the alteration of I 2 receptors has been associated with neurodegenerative and psychiatric disorders, among other brain dysfunctions,...
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Vitamin K: a Potential Neuroprotective Agent
Neurodegeneration, a progressive disease due to the arrested development of atrophy and regression of neuron function, is the most common disorder...
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Neuroprotective effect of apelin-13 and other apelin forms—a review
Neurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are...
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Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression
Depression is a highly prevalent mood disorder and one of the major health concerns in modern society. Moreover, it is characterized by a high...
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Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management
The gut microbiota that exists in the human gastrointestinal tract is incredibly important for the maintenance of general health as it contributes to...
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DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship
Parkinson’s disease (PD) usually occurs due to the degeneration of dopaminergic neurons in the substantia nigra (SN). Management of PD is restricted...
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
