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Enhancing solubility and bioavailability of coenzyme Q10: formulation of solid dispersions using Soluplus® as a carrier
Improving the aqueous solubility of poorly soluble compounds have been a major issue in the pharmaceutical industry. In the present study, binary...
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Ternary Solid Dispersion of Celecoxib Produced by the Solvent Method with Improved Solubility and Dissolution Properties
Celecoxib, the first cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug, has a wide range of pharmacological effects, including...
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Lyophilized Drug Product Cake Appearance: What Is Acceptable?
Cake appearance is an important attribute of freeze-dried products, which may or may not be critical with respect to product quality (i.e., safety...
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Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities
Artemongolins A – K ( 1–11 ), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through...
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Comparison of the Dissolution Profiles and Polymorph Study of Four Commercially Available Piroxicam Tablets
In this work, the dissolution profiles of four piroxicam tablets commercially available in Argentine were evaluated. All the four brands complied...
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Characterization and Determination of Freeze-Drying Properties of Frozen Formulations: Case Studies
It is quite critical prior to design of the lyophilization process to completely characterize the formulation and understand the thermal events and...
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Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product
The lyophilized high concentration protein drug products have the advantages of product stability suitable for ADC and other stability sensitive...
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A New Guaianolide-type Sesquiterpenoid and Xanthine Oxidase Inhibitory Activity from Chrysanthemum sinense Flowers
The ethanol extract of Chrysanthemum sinense Sabine, Asteraceae, flowers was found to inhibit xanthine oxidase with a IC 50 value of...
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Inhibitory Potential of Chemical Constituents from Paeonia suffruticosa Against α-Glucosidase and α-Amylase
Phytochemical study of the root bark of Paeonia suffruticosa plant led to the isolation and characterization of paeoniflorigenone ( 1 ),...
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Beyond pH: Acid/Base Relationships in Frozen and Freeze-Dried Pharmaceuticals
Stability of the majority of pharmaceuticals and biopharmaceuticals depends on acidity/basicity of the environment. In aqueous solutions,...
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Supramolecular Complex of Lappaconitine Hydrobromide and the Monoammonium Salt of Glycyrrhizic Acid: Synthesis, Physicochemical Characteristics, and Antiarrhythmic Activity
The aim of the work was to create new dosage forms of lappaconitine hydrobromide characterized by a modified mechanism and nature of drug release and...
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Diuretic Effect in Rats of Betulinic Acid, a Pentacyclic Triterpene from Citharexylum myrianthum
The diuretic effect of betulinic acid obtained from the hexane fraction of branches of Citharexylum myrianthum Cham., Verbenaceae, was evaluated in...
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Basic Operations
Weighing, volume measuring, particle size reduction, dispersing, dissolving and mixing, including checking each step, are key issues in all...
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Anti-inflammatory Clerodane Dinorditerpenoids from the Tinospora sinensis Leaves
Using various chromatographic methods, one new clerodane dinorditerpenoid, tinosinodane, and fourteen known compounds, tinosposinenside C,...
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Development of Industrial Technology of Inulin Production from Dandelion Roots (Taraxacum officinale Wigg.)
A method of extraction with forced circulation of extractant was used for exhaustive extraction of inulin from dandelion roots ( Taraxacum officinale Wi...
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Isolation, Characterization and Antibacterial Studies of Three New Chemical Constituents Isolated from Viburnum grandiflorum
Three new compounds “Viburnoate A–C” and two known compounds, namely, 4, 4-dimethyl-hexan-3-ol ( 1 ) and 4- tert -butyl-benzoic acid isobutyl ester ( 2 ) , ...
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Cytotoxic Potential of Phenolic Glycosides from Stipagrostis plumosa
Chemical analysis of the aqueous and n -butanol fractions of methanolic extract of Stipagrostis plumosa Munro ex T.Anderson, Poaceae, aerial parts led...
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Alkaloids of Gnaphalium polycaulon with Anti-Alzheimer’s Activity
Three alkaloids were isolated from the aerial parts of Gnaphalium polycaulon Pers., Asteraceae, collected from San Juan Huancollo, Ingavi Province,...
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Design and Process Considerations in Spray Freeze Drying
Dynamic spray freeze drying combines spray freezing and rotary freeze drying to generate homogeneous, free-flowing lyophilized beads as a bulk...