Abstract
Artemongolins A–K (1–11), which are undescribed sesquiterpenoid dimers, were obtained from Artemisia mongolica and characterized through comprehensive spectral data, including HRESIMS, IR, 1D and 2D NMR, and ECD calculations. The absolute configurations of compounds 1, 4, and 7 were undoubtedly determined by a single-crystal X-ray crystallography. Artemongolins A–K (1–11) featured a rare 5/7/5/5/5/10 hexacyclic system composed of a germacrene and a guaianolide by a fused 2-oxaspiro[4,4]nonane-1-one ring system. Antihepatoma evaluation against three human hepatoma cell lines demonstrated that the most active compounds 5 and 6 displayed inhibitory activity with IC50 values of 88.6 and 57.0 (HepG2), 59.1 and 26.4 (Huh7), and 67.5 and 32.5 (SK-Hep-1) µM, respectively.
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Acknowledgements
This work was financially supported by the Key Program of the National Natural Science Foundation of China (22137008), the **ngdian Yingcai Project (YNWR-KJLJ-2019-002), the Youth Innovation Promotion Association, CAS (2020386), the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province (202105AC160021).
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Shang, C., Ma, YB., Wang, Y. et al. Artemongolins A–K, undescribed germacrane-guaiane sesquiterpenoid dimers from Artemisia mongolica and their antihepatoma activities. Arch. Pharm. Res. 46, 782–794 (2023). https://doi.org/10.1007/s12272-023-01466-x
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DOI: https://doi.org/10.1007/s12272-023-01466-x