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Integration of Antioxidant Activity, Affinity Ultrafiltration, and Molecular Docking Simulations to Decipher the Tyrosinase Inhibitor of Embelia laeta
Embelia laeta (L.) Mez., Primulaceae, is mostly used by Chinese ethnic minorities. However, only little is known about its antioxidant chemical...
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Calixbenoquin: Calixarene-Based Cluster of Monobenzone as a New Anti-Tyrosinase Agent
Tyrosinase, copper-containing glycoprotein, is a key enzyme in the biosynthesis of melanin pigment from L-tyrosine. The excessive production of...
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Anti-elastase, Anti-tyrosinase, and Anti-inflammatory Activities of Three Compounds Isolated from Psorospermum aurantiacum: In Silico and In Vitro Assays
The hexane fraction of Psorospermum aurantiacum Engl., Hypericaceae, was found to prevent photo aging in skin cells lines. Therefore, this research...
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Design, Synthesis, Biological Activity and Molecular Docking Studies of New Imine-Chalcone Derivatives
Schiff base derivatives, owing to their non-toxic qualities and biodegradability are widely used in the pharmaceutical-chemical industry,...
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Essential Oil Contents of Hypericum linarioides, H. helianthemoides, and H. lydium with Their Biological Activities: Importance of Hypericum Genus in the Cosmeceutical and Pharmaceutical Industries
In the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the last ten years, especially for H. perforatum ....
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Synthesis, Antioxidant and Some Enzyme Inhibition Activities of New Sulfonyl Hydrazones and their Molecular Docking Simulations
In this work, a series of new sulfonyl hydrazones were synthesized and screened for antioxidant and anticholinesterase, tyrosinase and urease enzyme...
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Anti-melanogenic and Anti-inflammatory Activities of Hibiscus sabdariffa
Hibiscus sabdariffa L., Malvaceae, is traditionally cultivated for its stem, leaves, calyces, and seeds as all parts have industrial, medicinal, and...
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Anti-Melanogenic and Anti-Inflammatory Activities of Triterpenoids from Jatropha macrantha
Three pentacyclic triterpenes, the oleanolic acid, azarolic acid, and 3-oxo euscaphic acid, were isolated from the hexane extract of Jatropha macrantha ...
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In Vitro Evaluation of Antioxidant, Antimicrobial, Cytotoxic, Anti-Inflammatory, Anti-Aging, Enzyme Inhibition Potential, and HPLC Analysis of Traditionally Used Plant Delphinium Uncinatum Wall
Delphinium uncinatum Wall. (Ranunculaceae) is a native medicinal plant found on the sub-continent that is utilized to cure various human diseases....
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Phytochemistry and pharmacology of natural prenylated flavonoids
Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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Tyrosinase inhibitory components from the seeds of Cassia tora
Ten compounds ( 1 – 10) isolated from the seeds of Cassia tora were evaluated for tyrosinase inhibition. Compounds 3 , 4 , and 7 inhibited tyrosinase...
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Biomedical features and therapeutic potential of rosmarinic acid
For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a...
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Antibody-drug conjugates in cancer therapy: innovations, challenges, and future directions
The emergence of antibody-drug conjugates (ADCs) as a potential therapeutic avenue in cancer treatment has garnered significant attention. By...
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Nutraceuticals Derived from Dietary Spices as Candidate Molecules in Targeting Glioma Signaling Pathways
Spices have been used by people for generations as a source of food flavors to increase culinary delicacy. These ingredients not only give the food...
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Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies
BackgroundDehydrozingerone (DHZ) is an active ingredient of Zingiber officinale and structural half analogue of curcumin. In the present study, DHZ...
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Biological Activity of Condensed Pyridine Derivatives with a Bridgehead Nitrogen Atom
Data on the main types of biological activity of condensed pyridine derivatives with a bridgehead nitrogen atom, including the structures of the most...
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Endogenous estrogens—breast cancer and chemoprevention
Breast cancer is the most common female malignancy and the second leading cause of cancer related deaths. It is estimated that about 40% of all...
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Inhibition of PTP1B by farnesylated 2-arylbenzofurans isolated from Morus alba root bark: unraveling the mechanism of inhibition based on in vitro and in silico studies
Among the 2-arylbenzofuran derivatives isolated from Morus alba , the farnesylated 2-arylbenzofuran is a rarer constituent. The derivative has been...
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Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin, categorized by a burning sensation and eczematous lesions...
