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Application of 3D Whole-Brain Texture Analysis and the Feature Selection Method Based on within-Class Scatter in the Classification and Diagnosis of Alzheimer’s Disease
BackgroundPatients with mild cognitive impairment (MCI) are a high-risk group for Alzheimer’s disease (AD). Thus, a reliable prediction of the...
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Effect of Bumetanide Administration on the Pharmacoresistant Seizure to Lamotrigine in Electrical Amygdala Kindled Rats
In recent decades, 30 – 40 percent of epilepsy patients did not get relief from seizures by antiepileptic medications. In the present study, the...
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Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and...
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Neuroprotective effect of apelin-13 and other apelin forms—a review
Neurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are...
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Cannabidiol attenuates generalized tonic–clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain
BackgroundCannabidiol (CBD) has been of rapidly growing interest in the epilepsy research field due to its antiseizure properties in preclinical...
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Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis
Diffusion tensor imaging (DTI) is an imaging technique that uses magnetic resonance. It measures the diffusion of water molecules in tissues, which...
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Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders
The blood-brain barrier (BBB) is composed of specific tight junction proteins and transporters expressed on the lining of endothelial cells of the...
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Mindfulness meditation and psychedelics: potential synergies and commonalities
There has been increasing scientific and clinical interest in studying psychedelic and meditation-based interventions in recent years, both in the...
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Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish
BackgroundEpilepsy is a prevalent neurological disease, affecting approximately 1–2% of the global population. The hallmark of epilepsy is the...
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Role of oxidative stress in epileptogenesis and potential implications for therapy
In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of “redox messengers”. In a state of oxidative...
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A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central nervous system (CNS) leading to mental deterioration and...
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Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures
BackgroundThe aim of the study was to evaluate the brain-derived proteins, extracellular matrix-derived protein and cytokines as potential peripheral...
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Pre-empt aggression in prison and treat precipitating conditions
Violence significantly affects people in prison. While aggression may be exacerbated by environmental factors, violence may be reduced by early...
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Structural feature of TRAFs, their related human diseases and therapeutic intervention
Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor...
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Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review
During the period of mass industrial production of plastic products, the quality of human health has decreased significantly, especially in...
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Luteolin for neurodegenerative diseases: a review
Neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and multiple sclerosis affect millions of people...
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Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior
Accumulating evidence highlights chemokines as key mediators of the bidirectional crosstalk between neurons and glial cells aimed at preserving brain...
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Clinical significance of fluid biomarkers in Alzheimer’s Disease
AbstractThe number of patients with Alzheimer’s Disease (AD) and other types of dementia disorders has drastically increased over the last decades....
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Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration
BackgroundThe goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ -aminobutyric acid aminotransferase (GABA-AT) inhibitor...
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Effects of curcumin on neurological diseases: focus on astrocytes
Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative...
