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Role of the RAAS in mediating the pathophysiology of COVID-19
The renin-angiotensin-aldosterone system (RAAS) holds a position of paramount importance as enzymatic and endocrine homeostatic regulator concerning...
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Emerging roles of ferroptosis in liver pathophysiology
Ferroptosis is a widely recognized process of regulated cell death linking redox state, metabolism, and human health. It is considered a defense...
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Expand the treatment horizon of premenstrual dysphoric disorder with targeted therapeutic approaches
Premenstrual dysphoric disorder (PMDD) is a sex-specific cyclic mood disorder characterized by heterogenous mood and physical symptoms during the...
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Manage idiopathic hypersomnia with a combination of non-pharmacological and pharmacological treatments
Idiopathic hypersomnia (IH) is a rare slee** disorder that is difficult to diagnose, and little is known about its pathophysiology. A defining...
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Current and emerging immunobiologic therapies for atopic dermatitis
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease with a multifactorial etiology that affects up to 20% of children and up...
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Mechanisms of norcantharidin against renal tubulointerstitial fibrosis
Renal tubulointerstitial fibrosis (RTIF) is a common feature and inevitable consequence of all progressive chronic kidney diseases, leading to...
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Colchicine may be considered for the secondary prevention of cardiovascular disease
The acknowledgement of the significant role of inflammation in the pathophysiology of atherosclerosis has led to the investigation of...
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Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies
The desire to find a gold-standard therapy for depression is still ongoing. Develo** one universal and effective pharmacotherapy remains...
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Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...
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Mechanistic correlation of molecular pathways in obesity-mediated stroke pathogenesis
Obesity, a prominent risk factor for the development of heart attacks and several cardiovascular ailments. Obesity ranks as the second most...
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Intervention of Phytochemicals During Endometriosis and Their Conceivable Mechanisms
Endometriosis is a chronic and complex endocrine disorder that affects women of reproductive age. This syndrome is benign and is characterized by a...
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Targeting toxic forms of α-synuclein with immunotherapy could alter the progression of Parkinson’s disease
α-Synuclein is a presynaptic protein typically involved in synaptic regulation. However, it may form toxic aggregates and propagate in the CNS via...
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Deucravacitinib in plaque psoriasis: a profile of its use
Deucravacitinib (SOTYKTU™) is a tyrosine kinase 2 (TYK2) inhibitor that expands the availability of effective oral treatments for the management of...
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Potential of Nanoencapsulated Quercetin Topical Formulations in the Management of Diabetic Foot Ulcer
Diabetic foot ulcer originates due to peripheral neuropathy, immunosuppression, resistance to infections, and peripheral arterial disease. The...
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Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with hypertension, renin–angiotensin–aldosterone system pathway, and...
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Use of glucocorticoids and azithromycin in the therapy of COVID-19
In December 2019, a new variant coronavirus, SARS-CoV-2, emerged in China, which was initially described as a pneumonia of an unknown agent. The new...
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The impact of brivaracetam on cognitive processes and anxiety in various experimental models
BackgroundMemory deficits and anxiety symptoms are undesirable effects that occur in epilepsy patients. They may be associated with the...
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Targeting the CCL2-CCR2 axis in depressive disorders
Since affective disorders are considered to be underlain by the immune system malfunction, an important role in their pathophysiology is assigned to...
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Complicity of α-synuclein oligomer and calcium dyshomeostasis in selective neuronal vulnerability in Lewy body disease
α-Synuclein oligomers and Ca 2+ dyshomeostasis have been thoroughly investigated with respect to the pathogenesis of Lewy body disease (LBD). In LBD,...
