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Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties
Natural compounds known as phytochemicals have served as valuable resources for the development of new anti-cancer drugs and treatment of...
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Biofilm-associated genes as potential molecular targets of nano-Fe3O4 in Candida albicans
BackgroundThere are few effective treatments for Candida biofilm-associated infections. The present study demonstrated changes in the expression of...
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Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...
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Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery
The global pandemic of COVID-19 is a serious public health concern. Over 625 million confirmed cases and more than 6 million deaths have been...
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Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets
A balance between the development and suppression of inflammation can always be found in the body. When this balance is disturbed, a strong...
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Minor structural changes, major functional impacts: posttranslational modifications and drug targets
Posttranslational modifications (PTMs) are essential mechanisms that provide chemical diversity to proteins. The additional functional and structural...
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A Systematic Review on Chemical Actives from Plant Sources, Targets and Chemotherapy for Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) accounts for 15 – 20% of all other types of cancer. Due to the lack of target-specific compounds against...
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Deciphering the Antidiarrheal Mechanisms of Macleaya cordata by Combining Network Pharmacology, Molecular Docking, and Experimental Evaluations
Diarrhea continues to be a major public health problem and is thought to be the cause of 525,000 child fatalities annually. Studies have shown that Mac...
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Synthesis and In Silico Prediction of the Molecular-Targeting Anti-EGFR Action of a Novel Dihydroacridinone
The synthesis and in silico prediction of the molecular-targeted anti-EGFR inhibitory activity of a novel dihydroacridinone derivative are reported....
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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies
Sarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both...
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Scaffolds of Purine Privilege for Biological Cytotoxic Targets: A Review
The primary aim of this review is to emphasize and guide the biological cytotoxic activities of purine scaffold, also with a focus on emerging purine...
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Targeted Molecular Therapeutics for Pulmonary Diseases: Addressing the Need for Precise Drug Delivery
Respiratory diseases are a major concern in public health, impacting a large population worldwide. Despite the availability of therapies that...
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Unlocking the Potential of Brusatol as an Antitumoral Agent: Molecular Mechanisms and Therapeutic Benefits
Traditional Chinese medicine relies on brusatol to combat various diseases, including cancer. Considering the wide variety of natural substances and...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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Molecular Modeling and Cytotoxic Effects Of Biogenic Co(II) Nano Compounds
New Co(II) macrocyclic Schiff base complexes of type [MLCl 2 ] have been synthesized via a condensation reaction. The complexes were characterized by...
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The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
BackgroundThe new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified at the end of 2019. Despite growing understanding of...
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Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease
Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This...
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Low Molecular Weight NGF Mimetic Enhances the Overall Plasma Antioxidant Capacity in Rats with Streptozotocin-Induced Diabetes
Results from studies of the antidiabetic and antihyperglycemic activity of a low-molecular-weight NGF mimetic, compound GR-2 [bis-( N -monosuccinyl- L -glutamyl-...
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Recent Advances in the Pharmacological Properties and Molecular Mechanisms of Carvacrol
Plant secondary metabolites have received a lot of attention for their immense pharmacological activities and low side effects. Monoterpenes,...
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Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol...
