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Radioiodination and Biological Evaluation of Novel Quinoline Derivative for Infective Inflammation Diagnosis
This work is aimed at synthesizing a radiotracer of an iodoquinoline derivative of 2,2’-[(5-chloromethyl-8-hydroxyquinolin-7-yl) methylazanediyl]...
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KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain
BackgroundEpilepsy frequently coexists with neuropathic pain. Our approach is based on the search for active compounds with multitarget profiles...
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Biologically Active Substances From Dropwort (Filipendula vulgaris) and Assessment of Their Antioxidant Properties
This study demonstrated the antioxidant activity of aqueous and aqueous-ethanolic (40%, 70%, 95%) extracts of the above-ground parts of the dropwort (
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Drug Development and Analysis Review
The drug discovery has now evolved into a much more scientific and rational process due to better understanding of biological processes and the...
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The Antiradical Activity of Plant Tannins in Reactions with Electrochemically Generated Reactive Oxygen Species
The activities of tannins from various plant extracts prepared by electroextraction were studied in a reaction with oxygen radicals during cathodic...
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Quality Standards and Current Status of Ophthalmic Formulations in Indian Pharmacopoeia and National Formulary of India
The global ophthalmic formulations (OFs) market is expanding dramatically with the approval of new drug formulations for a variety of ophthalmic...
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Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines
New derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2- d ]pyrimidines based on 3-chloro derivatives of pyrano[3,4- c ]pyridines and...
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Voltammetry on Solid Electrodes for Qualitative Determination of Fenotropil and Piracetam in the Drug Substances, Dosage Forms, and Blood Plasma
A rapid, simple, specific, sensitive, and reproducible method for qualitative determination of fenotropil and piracetam in the drug substances,...
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Adsorption capacity of hydroxyapatite for several amino acids and heavy metal ions
The adsorption capacity of hydroxyapatite for several amino acids and heavy metal ions was investigated. The quantitative characteristics and laws of...
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Determination of clindamycin in dosage forms and biological samples by adsorption strip** voltammetry with carbon paste electrode
The electrochemical behavior of antibiotic drugs, clindamycin hydrochloride ( I ) and its phosphate salt ( II ), on carbon paste electrode (CPE) is...
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Early lifetime zinc supplementation protects zinc-deficient diet-induced alterations
Preclinical and clinical data indicate the involvement of zinc in the pathophysiology and therapy of depression. A relationship between...
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Analysis of thyrostatic heteroaromatic thioamides (review)
This review discusses methods widely used in pharmaceutical and clinical practice for the identification and assay of the thyrostatic agents...
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Adsorptive Strip** Voltammetric Determination of Irbesartan in Bulk and Pharmaceutical Products
Adsorptive strip** Voltammetric determination of irbesartan using a hanging mercury drop electrode (HMDE) is described. The method is based on...
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Electrochemical activity of alkaline salts of 5-amino-2,3-dihydrophthalazine-1,4-dione (luminol) and their ability to correct acid-base balance in cells
The electrochemical reduction of alkaline salts of 5-amino-2,3-dihydrophthalazine-1,4-dione was studied. These salts were able to increase the...
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Quality Control Methods for Group D Vitamins
Determination of the content of vitamin D is a rather difficult problem. In the present study, we have compared methods that are most widely used for...
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Polarographic study of sydnophen excretion from rat organism
The urinary excretion of sydnophen from rat organism has been studied using a polarographic technique for the first time. It is shown that...
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Electrochemical behavior and square wave voltammetric determination of aristolochic acid-I
Electroanalytical procedure for the determination of nephrotoxic aristolochic acid-l in the medicinal plant has been developed in the presence of...
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Acyl migration during alkylation of acetoxyurea derivatives
The alkylation of N-acetoxy-N-(benzofuran-2-yl)urea is performed in the presence of sodium hydride. This process is accompanied by the migration of...
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Antioxidant properties of extracts from the above-ground parts of Filipendula ulmaria
Extracts of the above-ground part of meadowsweet ( Filipendula ulmaria L. Maxim.) demonstrate a pronounced antioxidant activity. It is established...
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Voltammetric quality control of biologically active additives: determination of Zn, Cd, Pb, Cu, Fe, As, and Se
A new procedure for the voltammetric determination of toxic (As, Cd, Pb) and essential (Se, Cu, Zn, Fe) elements in various biologically active food...