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Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway
Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor...
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The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation
BackgroundMicroglia play a major role in the development of brain inflammation after central nervous system injury. On the other hand, microglia also...
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Muscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock
BackgroundTo compare pharmacologic effects of pirenzepine and AF-DX116, a selective competitive antagonist for M1 and M2 subtype muscarinic...
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Association Between the Post-Mortem and Poisoning Concentration of Tramadol and Its Main Metabolite and Genotype of CYP2D6
This study was aimed to investigate the association between the metabolic ratio of Tramadol and CYP2D6 polymorphism. For this purpose, the...
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Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...
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Advanced therapeutic strategies targeting microglia: beyond neuroinflammation
For a long time, microglia have been recognized as the main culprits of neuroinflammatory responses because they are primary phagocytes present in...
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Development of pharmacogenomic algorithm to optimize nateglinide dose for the treatment of type 2 diabetes mellitus
BackgroundNateglinide is a meglitinide used for the treatment of type 2 diabetes mellitus. Individual studies demonstrated the association of CYP2C9,...
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Crosstalk between angiogenesis and immune regulation in the tumor microenvironment
Cancer creates a complex tumor microenvironment (TME) composed of immune cells, stromal cells, blood vessels, and various other cellular and...
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Contribution of hyperglycemia-induced changes in microglia to Alzheimer’s disease pathology
Alzheimer’s disease (AD) is a neurodegenerative condition characterized by cognitive and functional impairments. The investigation of AD has focused...
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Nanomedicine – Immune System Interactions: Limitations and Opportunities for the Treatment of Cancer
Nanoparticles interact with immune cells in many different ways. These interactions are crucially important for determining nanoparticles’ ability to...
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The protective effects of statins in traumatic brain injury
Traumatic brain injury (TBI), often referred to as the “silent epidemic”, is the most common cause of mortality and morbidity worldwide among all...
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Antipsychotic drug—aripiprazole against schizophrenia, its therapeutic and metabolic effects associated with gene polymorphisms
Second-generation antipsychotics are widely used for the treatment of schizophrenia. Aripiprazole (ARI) is classified as a third-generation...
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Latest research progress on anticancer effect of baicalin and its aglycone baicalein
Cancer, which is a leading cause of deaths around the world, is characterized by genetic mutations and epigenetic changes. Baicalin and its aglycone...
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The Effect of Aerobic Training and Octopamine on Inflammatory Signaling Pathway in White Adipose Tissue of Rats Poisoned with Deep-Fried Oil
Increasing fat and poor diet impair the immune system by suppressing macrophages, but the beneficial effects of aerobic training (AT) and octopamine...
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Astragalus polysaccharide: a review of its immunomodulatory effect
The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus . This review aims to provide a...
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Distinctive role of inflammation in tissue repair and regeneration
Inflammation is an essential host defense mechanism in response to microbial infection and tissue injury. In addition to its well-established role in...
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Glycolytic metabolism supports microglia training during age-related neurodegeneration
Glucose is a major energy source for the brain, necessary to preserve proper neurophysiological functions; aberrant glucose metabolism in the brain...
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The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells
Although Warburg's discovery of intensive glucose uptake by tumors, followed by lactate fermentation in oxygen presence of oxygen was made a century...
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Anti-angiogenesis revisited: resha** the treatment landscape of advanced non-small cell lung cancer
Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the...
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Advances in plant-derived natural products for antitumor immunotherapy
In recent years, immunotherapy has emerged as a novel antitumor strategy in addition to traditional surgery, radiotherapy and chemotherapy. It...
