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The influence of cyclooxygenase inhibitors on kynurenic acid production in rat kidney: a novel path for kidney protection?
BackgroundKidney diseases have become a global health problem, affecting about 15% of adults and being often under-recognized. Immunological system...
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Protective effects of long-term nitrate administration against ovariectomy-induced kidney dysfunction in rats
BackgroundMenopause is associated with higher risks of chronic kidney disease. We determined the effect of nitrate on ovariectomy-induced kidney...
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Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury
BackgroundObstructive nephropathy is a condition often caused by urinary tract obstruction either anatomical (e.g., tumors), mechanical (e.g.,...
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Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms
Sodium–glucose cotransporter inhibitors (SGLT2i) are a new class of anti-diabetic drugs that have beneficial cardiovascular and renal effects. These...
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Pten knockout affects drug resistance differently in melanoma and kidney cancer
BackgroundPTEN is a tumor suppressor that is often mutated and nonfunctional in many types of cancer. The high heterogeneity of PTEN function between...
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Desidustat in anaemia in patients with chronic kidney disease: a profile of its use
Desidustat (Oxemia ™ ), a hypoxia-inducible factor prolyl hydroxylase inhibitor, is a promising new oral alternative to injectable...
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2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation
BackgroundKidney ischemia reperfusion injury (IRI) is characterized by tubular cell death. DNA double-strand breaks is one of the major sources of...
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Kynurenine pathway in kidney diseases
Kidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders...
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Prevalence, types and disclosure of complementary and alternative medicine (CAM) use among chronic kidney disease (CKD) patients in Saudi Arabia
IntroductionDespite the paucity of scientific evidence, CAM is widely used for the prevention and treatment of illness among patients with chronic...
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Astaxanthin- Enriched Fraction from the Microalga Haematococcus pluvialis Mitigates Kidney Injury via Modulation of Nrf2/Keap1 and MAPK/ERK Pathways in Rats
Acute kidney injury is a complication of using gentamicin in high doses and is associated with severe morbidity and mortality. Astaxanthin, the red...
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Difelikefalin in pruritus associated with chronic kidney disease: a profile of its use
Difelikefalin (Kapruvia ® ; Korsuva™), a novel peripheral kappa opioid receptor (KOR) agonist, is a promising emerging treatment for moderate-to-severe...
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Knowledge, attitude and perceptions of pharmacists regarding renal dose adjustment among chronic kidney disease patients in Pakistan
BackgroundChronic kidney disease (CKD) poses a significant public health challenge. CKD patients have compromised renal function, which not only...
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Assessing the Risk of Decrease in Kidney Function in Patients Prescribed Direct-Acting Antivirals for Hepatitis C Utilizing the MID-NET® Medical Information Database Network in Japan
An association between kidney disease and direct-acting antivirals against hepatitis C (DAAs) has been suggested, however the warning on the package...
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Improve medication adherence in older adults with chronic kidney disease by identifying and addressing underlying factors
Medication adherence is crucial to slowing disease progression and death in older adults with chronic kidney disease (CKD). However, as much as half...
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How Kidney Function Affects Drug Pharmacokinetics
The kidneyKidney is the most important organ for excretingPharmacokinetics (PK) drugs, including drugs metabolised by the liver, and impaired...
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Activation of β2 adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases
Beta 2 adrenergic receptor (β 2 -AR)-agonists, widely used as bronchodilators, have demonstrated wide-spectrum anti-inflammatory properties in both...
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Beneficial Effects of Punica granatum L. Juice and Gallic Acid Against Kidney Oxidative Damage Caused by Sodium Fluoride
The present work was undertaken to study the effect of sodium fluoride (NaF) exposure on renal oxidative stress status in rats and to evaluate the...
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Chronic Kidney Disease and End Stage Renal Disease
This chapter will describe the practice End stage renal disease (ESRD) essentials that are considered standard of care, common conditions and their...
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Acute Kidney Injury: Pre-renal, Intra-renal and Post-renal
Acute kidney injury (AKI) occurs when there is an acute fallAcute Kidney Injury (AKI) Pre-renal Intra-renal Post-renal in glomerular filtration...