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Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain
BackgroundA hallmark of psychostimulants is the persistence of neurobiological changes they produce. The difficulty in reversing long-time effects of...
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Investigation of the Membranotropic Properties of Acylated Peptide Derivatives of Dopamine and Serotonin Using the Pampa Method
Peptide derivatives of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) acylated with lauric acid (LA) and oleic acid (OA), including...
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A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective
The neural mechanisms and the receptors behind the course of chemotherapy-induced nausea and vomiting (CINV) are well described and considered...
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Approach the prevention of chemotherapy-induced nausea and vomiting in older patients with care
Chemotherapy-induced nausea and vomiting (CINV) negatively affects adherence to treatment and quality of life in older patients, and should be...
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1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia
BackgroundThe aim of the present study was to evaluate the effect of 1MeTIQ on fear memory and social interaction in an MK-801-induced model of...
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Effects of chronic delta-opioid receptor agonist on the excitability of hippocampal glutamate and brainstem monoamine neurons, anxiety, locomotion, and habituation in rats
BackgroundShort-term treatment with non-peptide agonists of delta-opioid receptors, such as agonist SNC80, induced behavioral effects in rodents,...
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Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein
BackgroundThe serotonin 5-HT 5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being...
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Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies
BackgroundDehydrozingerone (DHZ) is an active ingredient of Zingiber officinale and structural half analogue of curcumin. In the present study, DHZ...
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Network analysis of monoamines involved in anxiety-like behavior in a rat model of osteoarthritis
BackgroundChronic pain is a major health problem that affects a significant number of patients, resulting in personal suffering and substantial...
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Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats
BackgroundThe results of our previous studies demonstrated that low sensitivity to negative feedback (NF) is associated with increased vulnerability...
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Modulating role of serotonergic signaling in sleep and memory
Serotonin is an important neurotransmitter with various receptors and wide-range effects on physiological processes and cognitive functions including...
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Psychedelics action and schizophrenia
Psychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT) 2A receptor activation and induce several behavioral responses. They are of...
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Polypharmacology: promises and new drugs in 2022
Polypharmacology is an emerging strategy of design, synthesis, and clinical implementation of pharmaceutical agents that act on multiple targets...
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Diagnose and treat constipation- or diarrhoea-predominant irritable bowel syndrome with confidence
Irritable bowel syndrome (IBS) is diagnosed based on clinical criteria of regular abdominal pain and disordered defaecation. If first-line treatments...
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Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission
Background4-Iodo-2,5-dimethoxy- N -(2-methoxybenzyl)phenethylamine (25I-NBOMe) is a potent serotonin (5-HT) receptor agonist with hallucinogenic...
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The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats
BackgroundThe study aimed to assess the influence of a single valproate (VPA) administration on inhibitory and excitatory neurotransmitter...
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Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease
Huntington’s disease (HD) is a paradigm of a genetic neurodegenerative disorder characterized by the expansion of CAG repeats in the HTT gene. This...
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Cordia dichotoma Fruits Aqueous Extracts Alleviates Depressive-Like Behavior in a Rat Model via Regulating Serotonergic Neurotransmitters
Depression is a common mental illness caused by the interaction of social, psychological, and physical factors. The number of people suffering from...
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Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with...
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Exploring the Active Components of Ziziphus jujuba Mill. in Treatment of Depression by Network Pharmacology Combined with Neuroprotective Effects in SH-SY5Y Cells
Depression is a common mental health disease, with the characteristics of significant and persistent low mood. Traditionally, Ziziphus jujuba Mill . ...
