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Synthesis and Antimicrobial Action of Ninhydrin, Isatin, and 5-Acetyl-4-Hydroxy-1,3-Thiazine-2,6-Dione Derivatives Against Staphylococcus aureus and Pseudomonas aeruginosa Opportunistic Microflora
Series of new derivatives of ninhydrin, isatin, and 4-hydroxy-1,3-thiazine-2,6-dione were synthesized. Their antimicrobial activity against...
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Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel 3′-(6-(Substituted Phenyl)-4-Phenyl-6H-1,3-Thiazine-2-yl)Spiro[Indoline-3,3′-Isothiazolidine]-2,4′-Dione Derivatives
Thiazolidinediones (TZDs) are the vital component of a number of pharmaceuticals and biologically active compounds. Owing to the diversified...
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Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity
BackgroundTo verify the validity of the proposed pain treatment approach, which is based on concomitant blocking of the Transient Receptor Potential...
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Biopharmaceutical Study of an Injectable Dosage Form of the New Antiaggregant Substance 3-Methyl-8-(Piperazin-1-yl)-7-(Thietan-3-yl)-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione Hydrochloride
The pharmacokinetic parameters of the parent substance and the injectable dosage form of the new antiplatelet drug...
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Investigation into Anti-Alzheimer Activity of Newly Developed Phthalimide Derivatives in Experimental Animals
The present study was designed to investigate anti-Alzheimer’s activity and to quantify brain neurotransmitter of newly developed...
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Synthesis and Cytotoxic Activity of Indolo[2,3-a]Pyrrolo[3,4-c]Carbazole-5,7-Dione N-Glycosides Substituted on the Maleimide Nitrogen Atom
Reactions of indolo[2,3- a ]furano[3,4- c ]carbazole-5,7-diones with hydrazine hydrate, hydroxylamine hydrochloride, and formyl hydrazine produced the...
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Isolation and Cytotoxicity Estimation of Anthraquinone Derivatives from Alcoholic Extract of Rubia cordifolia Linn. Roots
Phytochemical evaluation of the alcoholic extract of Rubia cordifolia Linn. roots resulted in the identification of two anthraquinone compounds 1a ...
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Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
A series of new 3-(indol-3-yl)-4-(pyrazolo[3,4-c]pyridazin-3-yl)-maleimides were synthesized and evaluated for their inhibitory activity against...
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Antithrombotic Activity of the Steroids and ent-Kaurane Diterpenoids from Canna indica Rhizomes
Canna indica L . Cannaceae, is a valuable plant used for the treatment of many conditions. However, the scientific evidence to support the traditional...
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Synthesis and Cytotoxicity Against Human Breast Carcinoma Cell Evaluation of Some New 3,4-Disubstituted Coumarin Derivatives
A novel series of 3,4-disubstitutued coumarin derivatives have been synthesized by the reaction of ethyl coumarin-3-carboxylate with...
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Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives
1H-indol-2,3-dione (isatin) class of biologically active compounds have analgesic, anti-microbial, anti-inflammatory, anti-tubercular,...
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Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities
Two new flavones, namely 5-hydroxy-2-(4′-hydroxyphenyl)-6,12,13-trimethoxypyrano-xanthene-4,9-dione ( 1 ) and...
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An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activity
Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent...
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Novel serotonin 5-HT2A receptor antagonists derived from 4-phenylcyclohexane-5-spiro-and 5-methyl-5-phenyl-hydantoin, for use as potential antiplatelet agents
BackgroundAntiplatelet drugs have been used in the treatment of acute coronary syndromes and for the prevention of recurrent events. Unfortunately,...
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Efficient Synthesis of 21-Acetoxypregna-1,4,9(11),16-Tetraene-3,20-Dione, a Key Intermediate in the Synthesis of Highly Active Fluorinated Corticosteroids from 9α-Hydroxyandrostenedione
An efficient synthesis of 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione, a key intermediate in the synthesis of highly active fluorinated...
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Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.02, 6.08, 10]Dodec-11-Ene-3,5-Dione
A series of novel polycyclic N -amidoimides were synthesized by reacting 4-oxatetracyclo[5.3.2.0 2,6 .0 8,10 ]dodec-11-ene-3,5-dione with hydrazides of...
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Quantitative Determination of Angipur Drug Substance in Blood Plasma by HPLC with Fluorescence Detection
A quantitative determination method using HPLC with fluorescence detection for the xanthine derivative...
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Hypolipidemic Lactone Derivatives from Highland Barley Monascus
A new lactone, named 9-allyl-5-methyl-1H-difuro-isochromene-1,8-dione ( 1 ), together with nine known lactone derivatives ( 2–10 ), was isolated from...
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Synthesis, Antimicrobial Activity, α-Amylase Inhibitory Tests and Molecular Docking Studies of Thiazole Based Hydrazones Derived from 2-acyl-(1H)-indene-1,3(2H)-diones
A series of new thiazole based hydrazones have been synthesized and their antimicrobial and α-amylase (type-II diabetes) inhibitory activities have...
