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Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.02, 6.08, 10]Dodec-11-Ene-3,5-Dione

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Pharmaceutical Chemistry Journal Aims and scope

A series of novel polycyclic N-amidoimides were synthesized by reacting 4-oxatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione with hydrazides of benzoic acids, arylaminoacetic acid, and oxalic acid. The most pronounced antiviral activities against Vaccinia virus were observed for 4-hydroxy-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02, 6.08, 10]dodec-11-en-4-yl)-3-nitrobenzamide, N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-N′-[(3-trifluoromethyl)phenyl]ethanediamide, and N-(2,6-dimethylphenyl)-N′-(3,5-dioxo-4-azatetracyclo-5.3.2.02,6,08,10]dodec-11-en-4-yl)ethanediamide.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh, SB, RAS), 9 Prosp. Akad. Lavrent’eva, Novosibirsk 90, 630090, Russia

    B. A. Selivanov & A. Ya. Tikhonov

  2. Vector State Research Center for Virology and Biotechnology, Kol’tsovo, Novosibirsk Oblast, 630559, Russia

    N. I. Bormotov, L. N. Shishkina, E. F. Belanov, O. A. Serova, A. S. Kabanov & O. Yu. Mazurkov

Authors
  1. B. A. Selivanov
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  2. N. I. Bormotov
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  3. L. N. Shishkina
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  4. E. F. Belanov
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  5. O. A. Serova
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  6. A. S. Kabanov
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  7. O. Yu. Mazurkov
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  8. A. Ya. Tikhonov
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Corresponding author

Correspondence to A. Ya. Tikhonov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 10, pp. 3 – 7, October, 2018.

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Selivanov, B.A., Bormotov, N.I., Shishkina, L.N. et al. Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.02, 6.08, 10]Dodec-11-Ene-3,5-Dione. Pharm Chem J 52, 820–824 (2019). https://doi.org/10.1007/s11094-019-1907-9

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  • DOI: https://doi.org/10.1007/s11094-019-1907-9

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