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2,2′-Methoxyl Mono-Carbonyl Curcumin Promotes HEPG2 Cell Apoptosis and ROS Generation
Cancer, characterized by uncontrolled tumor cells growth, is a highly fatal disease worldwide. Molecular simplification of natural compounds is a...
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Reaction of Mercaptocarboxylic Acids with Carbonyl Compounds
A convenient and simple method for the synthesis of bis (carboxymethyl)thioacetals and -thioketals starting from the corresponding mercaptocarboxylic...
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Synthesis and Anxiolytic Activity of 9-(4-Ethylpiperazino-1-Carbonyl)Fluoren-9-OL Hydrochloride, A Structural Analog of the M-Choline Blocker Amizil
Experiments on rats in a depressive-like state model caused by reserpine employed the elevated plus-maze and open-field tests and showed that...
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Synthesis and Analgesic Activity of 4,10-Bis((±)-5-Benzoyl-2,3-Dihydro-1hpyrrolo[1,2-a]Pyrrole-1-Carbonyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazatetracyclo[5,5,03,11,05,9]Dodecane
A method of preparing the potential analgesic substance 4,10-bis((±)-5-benzoyl-2,3-dihydro-1 H -pyrrolo-[1,2- a ]pyrrole-1-carbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0...
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IN SILICO and IN VITRO Estimation of MAO-B Inhibitory Activity of Newly Synthesized Hydrazones Bearing a Pyrrole Heterocyclic System
This paper is focused on the in silico and in vitro determination of MAO-B inhibitory activity on recombinant MAO-B enzyme ( h MAOB) of newly...
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New Zn(II) Complexes of Pyrazole-Based Ligands: Synthesis, Characterization, and Inhibition of the Activity of Isoenzymes of Carbonic Anhydrase
Two new Zn(II) complexes of (4-benzoyl-1-(3-nitrophenyl)-5-phenyl-1 H -pyrazole-3-carbonyl)(5-sulfamoyl- 1,3,4-thiadiazol-2-yl)amide ( L 1 ) and...
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Physical Stability of Ibuprofen Upon Co-Milling with Caffeine and Polyvinylpyrrolidone at Room Temperature
The purpose of this work is to investigate the physical stability of a ternary amorphous system (Ibuprofen, Caffeine, Polyvinylpyrrolidone (PVP K30))...
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Protective Effect of Ellagic Acid on Induced Liver Injury
The application of one of the most important nonsteroidal anti-inflammatory drugs, diclofenac, has been restricted due to its hepatotoxicity. The...
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Effects of Liquiritin on Mitochondrial Dynamics in Cerebral Ischemia–Reperfusion Injury by Regulating Nurr1 via the YAP-INF2-Mitochondrial Fission Pathway
This study investigated whether liquiritin can alleviate cerebral ischemia–reperfusion injury by regulating Nurr1 to mediate mitochondrial...
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Alternative Synthesis of Cobimetinib
A novel approach for synthesis of Cobimetinib was reported, avoiding usage of a strong base in any of the steps with a chiral substrate. An efficient...
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Biofilm-associated genes as potential molecular targets of nano-Fe3O4 in Candida albicans
BackgroundThere are few effective treatments for Candida biofilm-associated infections. The present study demonstrated changes in the expression of...
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Co-Amorphous System (Paracetamol:Indomethacin): Investigations on Physical Stability and Intermolecular Interactions
To increase the performance of indomethacin (IND) by enhancing its water solubility and promoting its therapeutic efficiency, a ternary physically...
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Antiglycative Effect of Combination of Extracts of Capsicum annuum (chilli) and Pyridoxamine Against Glycation in Streptozotocin-induced Experimental Diabetes in Rats
Glycation causes the formation of advanced glycation end products, which play an important role in the pathogenesis of diabetic complications, which...
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Synthesis and In-Vitro Antimycobacterial Evaluation of 4-Arylidene-2-Phenyl-6-(Aryl)-4,5-Dihydropyridazin-3(2H)-One Derivatives
A series of 4-arylidene-2-phenyl-6-(aryl)-4,5-dihydropyridazin-3( 2H )-one derivatives ( 3a–3g and 3a’–3g’ ) have been synthesized and evaluated as...
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Morita Baylis Hillman Adduct Serves as Ligand in the Synthesis of Transition Metal Complexes Exhibiting Antibacterial Activity
In the present work, Morita—Baylis–Hillman (MBH) adduct ligand 3 was prepared under MBH reaction conditions. The compound was purified by...
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Extraction, Identification and Determination of Molecular Structure of Two Natural Compounds Along with Phytochemical Study of Hymenocrater calycinus Plant of the Lamiaceae Family Collected from Iran
The Iranian native plant called Hymenocrater calycinus (Boiss) Benth. of the Lamiaceae family, collected from the southern mountains of Khorasan...
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Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles that have attracted much attention in the field of...
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Creation of Modified Forms of Amiodarone with Glycyrrhizic Acid and Its Monoammonium Salt and Study of Their Cytotoxicity on Hela Cells
The aim of this work is to create new modified dosage forms of amiodarone with triterpene glycosides in various stoichiometric ratios and to study...
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Synthesis of 6-Substituted 3(H)-Quinazolin-4-Ones and Their Antimicrobial Activity
Three-step synthesis of 6-amino-3(H)-quinazolin-4-ones has been performed. Initially, the condensation of 3(H)-quinazolin-4-one was carried out in...
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Mononuclear Metal Complexes of Moxifloxacin with Antacids: Synthesis, Spectroscopic Characterization, and Antimicrobial Activities
Mononuclear metal complexes of 1-cyclopropyl-7-[( S , S )-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic...
