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Treat psoriasis with traditional and novel topical therapies
The mainstay topical treatments for psoriasis are corticosteroids and/or vitamin D analogues, with retinoids, calcineurin inhibitors, salicylic acid...
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Tapinarof cream 1% in plaque psoriasis: a profile of its use
Tapinarof (VTAMA ® ) cream 1%, a topical, non-steroidal, aryl hydrocarbon receptor agonist, presents a valuable addition to the therapy options for...
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The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver
BackgroundOur recent studies showed that prolonged administration of novel atypical antipsychotics affected the expression and activity of cytochrome...
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Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand
GPR35, an orphan receptor, has been waiting for its ligand since its cloning in 1998. Many endogenous and exogenous molecules have been suggested to...
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The role of mucosal barriers in human gut health
The intestinal mucosa is continuously exposed to a large number of commensal or pathogenic microbiota and foreign food antigens. The intestinal...
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Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-coupled receptors. Among them, FPR2 is a low affinity receptor...
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Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes
Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1,...
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Effects of phytoestrogens on reproductive organ health
Phytoestrogens are non-steroidal, polyphenolic compounds that are derived from plants and have biological properties similar to those of human...
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Influence of Urolithin a on Cytokine Production by Various Cancer Cell Lines
Urolithin A is a polyphenolic metabolite of ellagic acid and ellagitannins that is produced by the intestinal microbiota and has a higher...
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Indole-3-acetic acid ameliorates dextran sulfate sodium-induced colitis via the ERK signaling pathway
Microbiota-derived catabolism of nutrients is closely related to ulcerative colitis (UC). The level of indole-3-acetic acid (IAA), a...
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The influence of cyclooxygenase inhibitors on kynurenic acid production in rat kidney: a novel path for kidney protection?
BackgroundKidney diseases have become a global health problem, affecting about 15% of adults and being often under-recognized. Immunological system...
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Current and emerging immunobiologic therapies for atopic dermatitis
Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease with a multifactorial etiology that affects up to 20% of children and up...
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Astragalus polysaccharide: a review of its immunomodulatory effect
The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus . This review aims to provide a...
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Anticancer Activity–Structure Relationship of Quinolinone-Core Compounds: An Overall Review
Quinolinone/quinoline is one of the most unique structures in the discovery of heterocycles that have attracted much attention in the field of...
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Skin barrier dysfunction and filaggrin
Skin barrier dysfunction caused by endogenous or exogenous factors can lead to various disorders such as xerosis cutis, ichthyoses, and atopic...
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Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia
BackgroundChloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug. Recent studies...
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Secondary fungal infections in SARS-CoV-2 patients: pathological whereabouts, cautionary measures, and steadfast treatments
The earliest documented COVID-19 case caused by the SARS-CoV-2 coronavirus occurred in Wuhan, China, in December 2019. Since then, several SARS-CoV-2...
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Pharmacological effects of harmine and its derivatives: a review
Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has been used for thousands of years in the Middle East and China....
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Kynurenine pathway in kidney diseases
Kidney diseases have become one of the most common health care problems. Due to a growing number of advanced aged patients with concomitant disorders...
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Role of miR-653 and miR-29c in downregulation of CYP1A2 expression in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is a major contributor to the worldwide cancer burden. Recent studies on HCC have demonstrated dramatic...
