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Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line
BackgroundDrug resistance in endometrial cancer (EC) is a serious problem and a barrier to improving prognosis. The PI3K/AKT/mTOR pathway is highly...
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Alisol B 23-Acetate Affects a Podocyte Injury Model by Inhibiting PI3K/AKT/mTOR Signaling
Diabetic nephropathy is the leading cause of impaired renal function. Podocyte injury is a crucial factor during the pathological process of diabetic...
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Calycosin Induces Ferroptosis by SLC7A11 Through the PI3K/Akt Pathway in Acute Myelocytic Leukemia
Acute myelocytic leukemia seriously impairs the health and lifespan of patients; thus, effective treatment methods for acute myelocytic leukemia need...
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Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway
Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor...
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Cordycepin Inhibits Pathological High Shear-Induced Platelet Aggregation, Activation, and Phosphatidylserine Exposure by Regulating the Phosphorylation of Akt Protein
Cordycepin can effectively inhibit adenosine diphosphate-induced platelet aggregation; however, the inhibitory effect on shear-induced platelet...
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2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition
A growing proportion of the global adult and pediatric populations are currently affected by nonalcoholic steatohepatitis (NASH), leading to rising...
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Schisandrin B Inhibits Osteosarcoma Cell Proliferation and Promotes Apoptosis Through PI3K/AKT/mTOR Pathway Mediated Autophagy
Osteosarcoma is the most common primary malignant bone tumor; the main treatment method is surgery and adjuvant chemotherapy, with a 5-year survival...
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Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways
Insulin resistance (IR) is a key factor in the pathogenesis of disrupted glucose metabolism. Although the extract of Glycyrrhiza glabra has shown...
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Daidzein Relieves Lipopolysaccharide-Induced Mastitis Through Inhibiting MAPKs and AKT/NF-κB P65 Signaling Pathways
Mastitis in dairy cattle is a serious pathological process that causes significant economic losses to the farming industry. Daidzein is a dietary...
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PI3K/AKT Signaling Pathway–Mediated Three Flavonoids’ Modulation on Glucose Metabolism
Flavonoid-rich extracts of Hypericum attenuatum Fisch. ex Choisy, Hypericaceae, have been demonstrated to possess hypoglycemic activity. Astragalin,...
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Ginsenoside Rg2 Attenuates Doxorubicin-induced Cardiomyocyte Apoptosis via the PI3K/Akt Pathway
Doxorubicin, sold under the brand name Adriamycin among others, is an important drug for cancer therapy; however, its use is limited by its...
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Mangiferin ameliorates placental oxidative stress and activates PI3K/Akt/mTOR pathway in mouse model of preeclampsia
Preeclampsia is an inflammatory disease which can induce oxidative stress in placenta. Oxidative stress in preeclampsia is regulated by the...
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Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells
As the main metabolite of nitazoxanide, tizoxanide (TIZ) has a broad-spectrum anti-infective effect against parasites, bacteria, and virus. In this...
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A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway
Background2,4′,5′-Trihydroxyl-5,2′-dibromo diphenylmethanone (LM49), a novel active halophenol derivative synthesized by our group from marine...
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The Role of the HL-10 Peptide in Regulating the Expression of Apoptosis-Related Genes in the HeLa Cancer Cell Line
Anticancer peptides are among the most important bioactive peptides found in animal sources. The modulation of the molecular process of apoptosis via...
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Inhibitory effects of 6′-sialyllactose on angiotensin II-induced proliferation, migration, and osteogenic switching in vascular smooth muscle cells
Excessive production and migration of vascular smooth muscle cells (VSMCs) are associated with vascular remodeling that causes vascular diseases,...
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Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy
Natural compounds originating from plants offer a wide range of pharmacological potential and have traditionally been used to treat a wide range of...
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Nepetin, a natural compound from Inulae flos, suppresses degranulation and eicosanoid generation through PLCγ1 and Akt signaling pathways in mast cells
Nepetin derived from the flowers of Inula japonica , Inulae flos, has been reported to exert several biological activities, including...
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Paritaprevir ameliorates experimental acute lung injury in vitro and in vivo
Paritaprevir is a potent inhibitor of the NS3/4A protease used to treat chronic hepatitis C virus infection. However, its therapeutic effect on acute...
