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Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities
Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as compared to small cytotoxic molecules alone and have shown...
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(–)-cleistenolide and its Analogs as New Potential Antitumor Compounds Against PC-3 Cells
In order to find and develop new active compounds against prostate cancer, (–)-cleistenolide ( 1 ) and its 24 new analogs were evaluated for in vitro ...
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Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin, its Aminomethylated Derivative, and their Inclusion Complexes with Cyclodextrin
The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in...
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L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke
BackgroundL-proline transporter (PROT/SLC6A7) is closely associated with glutamatergic neurotransmission, where L-proline modulates the NMDA receptor...
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Nano-Nutraceuticals for Health: Principles and Applications
The use of nanotechnological products is increasing steadily. In this scenario, the application of nanotechnology in food science and as a...
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Kinetics of Omeprazole Release from Enteric Dosage Forms of Different Manufacturers
A comparative dissolution kinetics test (CDKT) related to proton-pump inhibitors (PPIs), particularly omeprazole, using dissolution media with pH 1.2...
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Common Deficiencies Found in the Active Pharmaceutical Ingredient (API) Section of Non-sterile Generic Products Submitted for Registration by SAHPRA
PurposeThis research study aims to determine the qualitative and quantitative common deficiencies included in the API section of dossiers submitted...
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Synthesis and Biological Activity of 4-(3,4-Dibromothiophenecarbonyl)-2,6,8,10,12-Pentaacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane: A New Non-Narcotic Analgesic of the Hexaazaisowurtzitane Class
A method for production of a promising non-narcotic analgesic of the hexaazaisowurtzitane class is developed. Data on the physicochemical...
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Change in Chromatographic Parameters of Some Phenylpropanoids in Different Mobile Phases Under Reversed-Phase HPLC Conditions
The effect of the eluent composition (type and concentration of the organic and acid components) on the retention times and selectivity of the...
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Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect
BackgroundVortioxetine hydrobromide (VXT), a new therapeutic option in the treatment of major depressive disorder, is a poorly soluble drug, and...
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Evaluation of epithelial transport and oxidative stress protection of nanoengineered curcumin derivative-cyclodextrin formulation for ocular delivery
Ocular drug delivery has been a well-known route for the drug administration for the treatment of ocular diseases. However, numerous anatomical and...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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Studies of the Possibility of Using Renal Biomarkers to Assess Drug Nephrotoxicity in an RPTEC/TERT1 Cell Line Model
We report here studies of the possibility of using contemporary biomarkers of in vivo kidney damage - cystatin C and clusterin – in the RPTEC/TERT1...
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Inclusion Complex of 11-deoxymisoprostol and Glycyrrhizic Acid with Improved Anti-Ulcer Activity
A 1:4 inclusion complex of 11-deoxymisoprostol ( II ) with glycyrrhizic acid (complex III ) was synthesized and exhibited high anti-ulcer activity in...
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QUALITY REQUIREMENTS FOR HERBAL DRUGS; ANALYTICAL METHODS
In the broadest sense, all plants that are used for healing purposes, based on either traditional use or scientific data, are referred to as...
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PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine
Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), is indicated for the treatment of major depressive disorder, social anxiety...
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The Prospects of 5-Androstenediol and its Synthetic Derivatives as Novel Radioprotective Drugs
The steroid hormone 5-androstenediol (5-AED) has been advanced as a possible countermeasure for protection from ionizing radiation. It is highly...
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Glycoalkaloids of Plants in the Family Solanaceae (Nightshade) as Potential Drugs
Worldwide interest in medicinal plants and related drugs is growing because of the increased spectrum of new synthetic drugs. In this context,...
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Development of a Quantitative Determination Technique for Ascorbic Acid in Medicines
A coordination compound of iron(III) ion with 1,10-phenanthroline, or the oxidized form of ferroin (OFF), which was obtained via the reaction of...
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Be aware of the risks of nephrotoxicity when prescribing amoxicillin and third-generation cephalosporins
Amoxicillin and third-generation cephalosporins are widely used in the prevention and treatment of established infections. These broad-spectrum...