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The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke
BackgroundDiabetes is an independent risk factor of stroke and previous studies have confirmed that diabetic patients and animals experience poorer...
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Contribution of changes in the orexin system and energy sensors in the brain in depressive disorder - a study in an animal model
BackgroundMaternal elevated glucocorticoid levels during pregnancy can affect the develo** fetus, permanently altering the structure and function...
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Liquiritin Relieves LPS-Induced Endometritis Through Activating Keap1/Nrf2/HO-1 Signaling Pathway
Liquiritin is a flavonoid extracted from Glycyrrhiza glabra L., Fabaceae, which possesses anti-inflammatory and antioxidant activities. However, the...
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Intrathecal pramipexole and selegiline for sensory and motor block in rats
BackgroundThe purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the...
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Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer
Prostate cancer is the second most prevalent cancer in men worldwide. The TRIM (tripartite motif) family of proteins is involved in the regulation of...
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Inhibitors of Nitric Oxide Production from the Seeds of Myristica fragrans: Experimental and Computational Results
This study focuses on the extraction of eleven compounds from Myristica fragrans Houtt., Miristicaceae, seeds, guided by their anti-inflammatory...
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Alisol B 23-Acetate Affects a Podocyte Injury Model by Inhibiting PI3K/AKT/mTOR Signaling
Diabetic nephropathy is the leading cause of impaired renal function. Podocyte injury is a crucial factor during the pathological process of diabetic...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model
Experimental results for the new nerve growth factor (NGF) mimetic GK-2 [ bis -( N -monosuccinyl- L -glutamyl- L -lysine)hexamethylenediamide] administered...
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Protective effects of 6,7,4′-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells
Daidzein, one of the important isoflavones, is extensively metabolized in the human body following consumption. In particular,...
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Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin, its Aminomethylated Derivative, and their Inclusion Complexes with Cyclodextrin
The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in...
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The impact of brivaracetam on cognitive processes and anxiety in various experimental models
BackgroundMemory deficits and anxiety symptoms are undesirable effects that occur in epilepsy patients. They may be associated with the...
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Synthesis and Cerebrovascular Activity of Nicotinoyl-L-Proline
The cerebrovascular activity of the new synthesized compound nicotinoyl- L -proline in rats with acute ischemia caused by occlusion of the left carotid...
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Early Detection of Toxic Cyanobacteria in Bulgarian Dam Water and In Vitro Evaluation of the Effect of Saponins From Astragalus glycyphyllos and A. glycyphylloides, in Cyanotoxin (Anatoxin-α)-Induced Neurotoxicity
As a result of the blooming, certain Cyanobacteria ( i.e ., Microcystis ) produce toxins, at concentrations that could be toxic. In this study, a group...
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Crocin Administration Represses Depressive-Like Behaviors in Rats by Targeting the Hippocampal miRNA-99A/FKBP51/PSD-95 Level
We investigated the role of miR-99a in regulating depressant activity by administering crocin in an animal model of chronic unpredictable mild stress...
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Ketamine treatment protects against oxidative damage and the immunological response induced by electroconvulsive therapy
BackgroundElectroconvulsive therapy (ECT) is often recommended for major depressive disorder (MDD) for those who do not respond to the first and...
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Protective effects of l-theanine on rats with dextran sulfate sodium-induced inflammatory bowel disease
The aim of this study is to evaluate the anti-inflammatory and protective effects of l -theanine in inflammatory bowel disease (IBD) and to identify...
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An in vitro evaluation of the antioxidant activities of necroptosis and apoptosis inhibitors: the potential of necrostatin-1 and necrostatin-1i to have radical scavenging activities
BackgroundNecroptosis inhibitors, including necrostatin-1 (Nec-1), are attracting attention as potential therapeutic agents against various diseases,...
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Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders
Women are significantly more likely to develop depression than men. Fluctuations in the ovarian estrogen hormone levels are closely linked with...
