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PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug–drug interactions with clarithromycin and paroxetine
Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), is indicated for the treatment of major depressive disorder, social anxiety...
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Trilaciclib for the reduction of chemotherapy-induced myelosuppression in the management of extensive-stage small cell lung cancer: a profile of its use
Trilaciclib (COSELA™) is a transient inhibitor of cyclin-dependent kinases 4 and 6 (CDK 4/6) that is approved in the USA to decrease the incidence of...
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The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
BackgroundThe new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified at the end of 2019. Despite growing understanding of...
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Platelets in COVID-19 disease: friend, foe, or both?
Immuno-thrombosis of COVID-19 results in the activation of platelets and coagulopathy. Antiplatelet therapy has been widely used in COVID-19 patients...
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Inhibitors of Sortases of Gram-Positive Bacteria and their Role in the Treatment of Infectious Diseases (Review)
The functions of sortase bacterial enzymes and their surface-protein substrates are reviewed. Their role in the pathogenesis of infectious diseases...
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Identification of Novel Peptides Targeting DNA Methyltransferase 1 (DNMT-1) for Breast Cancer Treatment
Epigenetic alteration shows an essential role in the process of breast cancer cell proliferation and propagation. DNA methyltransferase (DNMT) is...
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Don’t Rely on Your Prescription
Most likely it’s not working for you. When you are prescribed a medicine and take it, you do so in the hope that you will have a benefit from it. Why...
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DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship
Parkinson’s disease (PD) usually occurs due to the degeneration of dopaminergic neurons in the substantia nigra (SN). Management of PD is restricted...
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Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats
BackgroundCurcumin, a natural polyphenol from Curcuma longa, is known to possess diversified pharmacological roles including anti-inflammatory,...
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Lurasidone in schizophrenia in adolescents: a profile of its use
The second-generation (atypical) antipsychotic lurasidone (Latuda ® ) presents a useful option to consider for the treatment of schizophrenia in...
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Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats
BackgroundVascular endothelial growth factor A (VEGF-A) and P2-receptors (P2Rs) are involved in the pathogenesis of diabetic nephropathy. The...
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Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts
Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in cholesterol biosynthesis, that are highly effective in reducing...
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Pharmacological Effects, Pharmacokinetics, and Strategies to Reduce Brucine Toxicity
Semen strychni , the seed of Strychnos nux-vomica L., Loganiaceae, has been widely used in China for a long history. Brucine, one of the main...
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Impact of selected genetic factors on clopidogrel inactive metabolite level and antiplatelet response in patients after percutaneous coronary intervention
Background and objectiveClopidogrel is frequently used as part of optimal dual antiplatelet therapy in high-bleeding risk patients with the acute...
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Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles
Gastric cancer (GC) is one of the most prevalent malignancies in the world, with a high mortality rate in both women and men. Conventional...
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IL-1 and CD40/CD40L platelet complex: elements of induction of Crohn’s disease and new therapeutic targets
Ulcerative colitis (UC) and Crohn’s disease (CD) are chronic and multifactorial diseases that affect the intestinal tract, both characterized by...
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Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review)
Studies of the pharmacotherapy of gastro-intestinal stromal tumor as examples of personalized medicine are reviewed. Peculiarities of the use of...
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Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine
BackgroundAlthough highly active antiviral therapies (HAART) exert control over viral replication in persons with Acquired Immunodeficiency Syndrome...
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Recycling Preparative Liquid Chromatography, the Overlooked Methodology for the Purification of Natural Products
Frequently, preparative high-performance liquid chromatography separations of complex natural product mixtures by adsorption chromatography are...
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Gout plus cardiovascular disease is painful, but treatable
Gout often coexists with and worsens cardiovascular disease (CVD) or CVD risk factors. Effective gout management reduces CVD deterioration, which...
