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Setosphapyrone C and D accelerate macrophages cholesterol efflux by promoting LXRα/ABCA1 pathway
LXRα agonists have attracted significant attention due to their potential biological activities on promoting cholesterol efflux. This study was...
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Molecular mechanism of ferulic acid and its derivatives in tumor progression
Cancer is a significant disease that poses a major threat to human health. The main therapeutic methods for cancer include traditional surgery,...
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2-Geranyl-1-methoxyerythrabyssin II alleviates lipid accumulation and inflammation in hepatocytes through AMPK activation and AKT inhibition
A growing proportion of the global adult and pediatric populations are currently affected by nonalcoholic steatohepatitis (NASH), leading to rising...
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Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics
Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of non-erosive reflux disease (NERD), ulcers associated with...
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Inhibition of Human CYP1A1/A2 by a Hydroalcoholic Extract and Its Neolignan Constituents from Piper rivinoides
Lignans and neolignans, commonly found in plants, are generally composed of two phenylpropane (C 6 -C 3 ) units with a marked diversity of molecular...
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Calycosin Inhibits Pulmonary Fibrosis Through the Regulation of miR-375/YAP1 Signaling Pathway
Pulmonary fibrosis is a chronic lung disease characterized by epithelial-mesenchymal transition. Calycosin, the main active flavonoid isolated from...
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Dysregulation of histone deacetylases in ocular diseases
Ocular diseases are a growing global concern and have a significant impact on the quality of life. Cataracts, glaucoma, age-related macular...
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In-Silico Study, Preparation and Biological Evaluation of 99MTC-Mesalamine Complex as Radiotracer for Diagnostics and Monitoring of Ulcerative Colitis in Mice
This work centralizes on pursuit ulcerative colitis localized in mice. High radiolabeling and purity were ensured during the formation of a...
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Treat psoriasis with traditional and novel topical therapies
The mainstay topical treatments for psoriasis are corticosteroids and/or vitamin D analogues, with retinoids, calcineurin inhibitors, salicylic acid...
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Structural feature of TRAFs, their related human diseases and therapeutic intervention
Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor...
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M-134, a novel HDAC6-selective inhibitor, markedly improved arthritic severity in a rodent model of rheumatoid arthritis when combined with tofacitinib
BackgroundAlthough tofacitinib has shown highly significant efficacy for rheumatoid arthritis (RA), there are still a considerable number of patients...
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Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway
Insulin signaling and lipid metabolism are disrupted by long-term consumption of a high-fat diet (HFD). This disruption can lead to insulin...
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Pharmacokinetic Study of Tilianin After Oral Administration in Wistar Rats by HPLC
Tilianin was obtained from the medicinal plant Agastache mexicana (Kunth) Lint & Epling, Lamiaceae, a compound that is candidate to develop new...
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Anti-angiogenesis revisited: resha** the treatment landscape of advanced non-small cell lung cancer
Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the...
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Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a tumor with poor prognosis and frequently aggressive. The development of HCC is associated with fibrosis and...
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Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment
Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent diseases ranging from cancer and Alzheimer’s disease to...
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Exploring the therapeutic potential of natural compounds modulating the endocannabinoid system in various diseases and disorders: review
Cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes involved in the biosynthesis and degradation of the...
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Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience
BackgroundGraves’ orbitopathy (GO) is an autoimmune disorder of the orbit and retro-ocular tissues and the primary extrathyroidal manifestation of...
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Hepatoprotective potential of 7,8-Dihydroxyflavone against alcohol and high-fat diet induced liver toxicity via attenuation of oxido-nitrosative stress and NF-κB activation
Background : Fatty liver diseases are the most common and major health concern arises from the modern lifestyle and alcohol (ethanol) abuse. The...
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Lipid-lowering drugs and cancer: an updated perspective
Statins and non-statin medications used for the management of dyslipidemia have been shown to possess antitumor properties. Since the use of these...
