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Effect of Phenolic Acids and Flavonoids on Low Dose Caffeine-Induced Adipogenesis and Oxidative Stress in 3T3-L1 Adipocytes
Obesity is characterised by an excessive build-up of lipids and triglycerides in adipocytes. Phenolic acids and flavonoids have previously been shown...
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Validated RP-HPLC Method Development for Gentamicin Microanalysis in Pharmaceutical Dosage Forms, Urine and Blood
Gentamicin is an important member of the aminoglycoside class of antibiotics having broader spectrum with extend to ototoxicity and nephrotoxcity. A...
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Leveraging electronic logistics management information systems to enhance and optimize supply chain response during public health emergencies: lessons from COVID-19 response in Uganda
BackgroundHealth supply chain is crucial for proper functioning of a health system and advancing national and international health security goals....
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Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem mass spectrometry analytical method development, cross-validation, and clinical application
BackgroundMycophenolic acid (MPA) is widely used in posttransplant pharmacotherapy for pediatric patients after renal transplantation. Volumetric...
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Development and validation of a quantification method for α-humulene and trans-caryophyllene in Cordia verbenacea by high performance liquid chromatography
Acheflan® herbal medicine is the first medicine developed and produced in Brazil using Cordia verbenacea DC., Boraginaceae, essential oil as a...
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Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Erythromycin Related Impurities in Topical Dosage Form
Arobust, specific, sensitive, and precise reverse-phase HPLC method has been developed to determine a typical antibiotic drug erythromycin and...
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Determination of Protoapigenone in Beagle Dog Plasma by LC–MS/MS: Application to a Pharmacokinetic Study
Protoapigenone, a unique class of natural flavonoid, exerted significant cytotoxic and antitumoral activities. A simple, sensitive, and rapid...
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Phenolic Compounds and Radical Scavenging Activity of Senna tora (L.) Roxb. Herbs Collected from Various Geographical Locations of India
Senna tora (L.) Roxb. syn Cassia tora L., commonly known as sickle pod, is widely distributed in tropical Asian countries. Various parts of the plant...
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Simultaneous quantification of six flavonoids in four Scutellaria taxa by HPLC-DAD method
The objective of this study was to develop and validate a new HPLC method to quantify several flavonoids in the methanol extract prepared from the...
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Determination of Palladium as an Elemental Impurity in Ropivacaine Hydrochloride Monohydrate by Atomic Absorption Spectrometer
According to an International Conference on Harmonization (ICH), a catalyst used during the synthesis process of drugs may be present in trace levels...
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Quantitative Analysis of Tranexamic Acid Using 2,6-Dichloroquinone-4-Chlorimide as Chromogen: Kinetic Approach
Coupling of 2,6-dichloroquinone-4-chlorimide (DCQ) with tranexamic acid (TA) resulted in a greenish-brown colored complex which absorbed at λ max =...
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Determination of Salidroside and Betaine by 1H NMR for Quality Control of **nnaoxin Commercial Products
A validated and sensitive 1 H NMR method was developed for the qualitative and quantitative analysis of the two main components of “xinnaoxin”...
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Development and Validation of the UV Spectrophotometric Method for Simultaneous Determination of Paracetamol and Pseudoephedrine in Bulk and Combined Tablet Dosage Form
Paracetamol (PARA) and Pseudoephedrine (PSE) are co-formulated drugs that and widely used over the world for the treatment of symptoms associated...
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An eco-friendly method for extraction and quantification of flavonoids in Dysphania ambrosioides
Dysphania ambrosioides (L.) Mosyakin and Clemants (Syn: Chenopodium ambrosioides L.), Amaranthaceae, is a plant with antibacterial, antifungal,...
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Inhibitory Effects and Related Molecular Mechanisms of Huanglian-Ganjiang Combination Against H1N1 Influenza Virus
Influenza is an infectious acute respiratory disease with complications and a high mortality rate; the effective medicines for influenza therapy are...
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Development of a Simple Isocratic HPLC-UV Method for the Simultaneous Analysis of Repaglinide and Metformin Hydrochloride in Nanoemulsion Formulations and Commercial Tablets
This study was aimed to develop and validate an HPLC-UV method for simultaneous analysis of metformin HCl (MET HCl) and repaglinide (REP) in...
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Copalic Acid: Occurrence, Chemistry, and Biological Activities
(–)-Copalic acid is a naturally occurring labdane‐type diterpene acid usually isolated from oleoresins of Copaifera trees, being considered the...
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Development and Validation of a Stability-Indicating HPLC-DAD Method for the Determination of Canagliflozin and Metformin Simultaneously in Combination Dosage Form
The purpose of this study was to develop and validate a rapid, simple, easy, and precise high-performance liquid chromatography (HPLC) method with...
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Comparative Study of the Quantitative Determination of Lappaconitine in Aconitum septentrionale by High-Performance Liquid Chromatography and Spectrophotometry
Methods for quantification of total alkaloids in terms of lappaconitine in Aconitum septentrionale Koelle, a plant raw material that is the main...
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Quantification of major phenolic and flavonoid markers in forage crop Lolium multiflorum using HPLC-DAD
The objective of this study was to perform preliminary screening of phytochemical compounds and quantification of major phenolics and flavonoid...