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Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors
BackgroundIn this article, a series of 20 new thiosemicarbazone derivatives containing indole were synthesized and evaluated for their...
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Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury
Sonic Hedgehog (SHh) is a homology protein that is involved in the modeling and development of embryonic tissues. As SHh plays both protective and...
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Non-alcoholic fatty liver disease and liver secretome
Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and contributes to the body's homeostasis by secreting a variety...
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Anti-amnesic and Neuroprotective Potential of Genistein Against Alzheimer’s Disease
Alzheimer’s disease, the most prevalent neurodegenerative disorder, is characterized by language deficits, impairment of problem-solving ability,...
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Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway
Systemic or hepatic inflammation is caused by intraperitoneal application of lipopolysaccharide (LPS). In this study, we investigated...
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1, 25-Dihydroxyvitamin D3 activates Apelin/APJ system and inhibits the production of adhesion molecules and inflammatory mediators in LPS-activated RAW264.7 cells
Background1, 25-Dihydroxyvitamin D3 (1, 25(OH) 2 D 3 ), an active form of vitamin D3, plays a crucial role in the mitigation of inflammation damage....
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FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling
Background and aimThis study evaluates a novel benzylidene-chromanone derivative, FNF-12, for efficacy in in vitro and in vivo asthma models.
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Anti-inflammatory and Antinociceptive Activities of the Hydroalcoholic Extract and the Volatile Fraction of Southeastern Brazilian Brown Propolis
The analgesic and anti-inflammatory activities of a Southeastern Brazilian brown propolis were evaluated using the formalin test and...
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Cinnamon Modulates Toll-Like Receptors: a New Therapeutic Approach for Diabetes
AbstractDiabetes mellitus is a chronic metabolic disease with a high global incidence that can lead to serious and life-threatening conditions....
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Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-associated molecular patterns (PAMPs) and danger-associated...
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Potential of natural products in inflammation: biological activities, structure–activity relationships, and mechanistic targets
A balance between the development and suppression of inflammation can always be found in the body. When this balance is disturbed, a strong...
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Daidzein Relieves Lipopolysaccharide-Induced Mastitis Through Inhibiting MAPKs and AKT/NF-κB P65 Signaling Pathways
Mastitis in dairy cattle is a serious pathological process that causes significant economic losses to the farming industry. Daidzein is a dietary...
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Anti-Inflammatory Activity of Benzyl Glycosides from the Flowers of Lilium Asiatic Hybrids
Repeated column chromatography of solvent fractions extracted from the flowers of Lilium Asiatic hybrids ensured purification of three benzyl...
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Rosmarinus officinalis Volatile Oil Nanogel Modulated Muscle Damage Induced by Bothrops moojeni Venom: a Phonophoresis Method
Bothrops moojeni venom contains toxins that induce local toxic effects, leading to a severe inflammatory process, pain, hemorrhage, edema, and...
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Role of Neutrophils as Therapeutic Targets in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a major health problem. It is one of the most common types of stroke and results in mortality in approximately half...
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The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation
BackgroundMicroglia play a major role in the development of brain inflammation after central nervous system injury. On the other hand, microglia also...
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Protective Effect of Ellagic Acid on Induced Liver Injury
The application of one of the most important nonsteroidal anti-inflammatory drugs, diclofenac, has been restricted due to its hepatotoxicity. The...
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The immunosuppressive effect of the endocannabinoid system on the inflammatory phenotypes of macrophages and mesenchymal stromal cells: a comparative study
BackgroundThe inflammatory sequence is the first phase of wound healing. Macrophages (MPhs) and mesenchymal stromal cells (MSCs) respond to an...
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Vascular adhesion protein-1 and microvascular diabetic complications
Vascular adhesion protein-1 (VAP-1) is a bifunctional protein that has the ability to catalyze the deamination of primary amines and is involved in...
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In Vivo Study to Explore the Antiarthritic Potential of Tiliroside on Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats
The purpose of this research was to examine the pharmacological properties and potential mechanism of action of tiliroside in rheumatoid arthritis....
