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Association between chemotherapy and plasma adipokines in patients with colorectal cancer
Background : A link between chemotherapy, the serum level of selected adipokines and clinical outcome in colorectal patients was investigated.
Methods :...
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Preventative measures and prompt recognition are crucial in managing dopamine agonist withdrawal syndrome
There are currently no effective therapies for treating dopamine agonist withdrawal syndrome. Preventative measures, including judicious use of...
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Pharmacotherapy of Pathological States of Adrenal Glands (Review)
Recent advances in the pharmacological treatment of hormonal hyperfunction and insufficiency of adrenal glands were reviewed.
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Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases
BackgroundThe main types of inflammatory bowel diseases (IBD) are ulcerative colitis (UC) and Crohn’s disease (CD). There is evidence that, in...
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RDD e PDD: strumenti per l’aderenza e la persistenza nelle analisi di farmacoutilizzazione: il caso degli analoghi della somatostatina (2007–2011)
BackgroundLanreotide and octreotide are used to treat patients suffering from neuroendocrine tumors and acromegaly.
ObjectivesIn order to assess...
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Non-nuclear localization of Ki-67 in human colorectal cancer cells grown as multicellular layers
Multicellular layers (MCL) of cancer cells is an in vitro 3-dimensional (3D) model that mimics avascular microregions of human solid tumors and has...
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Statistical Evaluation of Drug Safety Data
There has been growing awareness of the importance of the statistical evaluation of drug safety data both in the premarketing and postmarketing...
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Antirheumatika und Antiphlogistika
In der Therapie rheumatischer Erkrankungen einschließlich degenerativer Veränderungen werden vorzugsweise nichtsteroidale Antiphlogistika eingesetzt...
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Biological Activity of Organogermanium Compounds (A Review)
Data on the main biologically active organogermanium compounds that were synthesized in the past 5 – 10 years were reviewed. The dietary trace...
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Urethane increases reactive oxygen species and activates extracellular signal-regulated kinase in RAW 264.7 macrophages and A549 lung epithelial cells
Urethane, which is used as an anesthetic for animal experiments, causes inflammation and cancer in the lung. BALB/c mice received 1 mg/g of urethane...
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Hyaluronan: Towards novel anti-cancer therapeutics
The understanding of the role of hyaluronan in physiology and various pathological conditions has changed since the complex nature of its synthesis,...
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Valutazione economica dei programmi di screening contro il cancro del colon retto: evidenze indirette di lungo periodo e sostenibilità finanziaria in un’ottica di programmazione regionale
BackgroundAbout 37,733 new cases of colorectal cancer (CRC) are yearly diagnosed in Italy. Abruzzo regional estimates for 2008 report 902 new cases,...
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Human Cytochrome P450 Enzymes
The cytochrome P450 (P450) enzymes first attracted interest because of their relevance to the metabolism of drugs, steroids, and carcinogens....
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Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis
BackgroundIn addition to recognized antimalarial effects, Artemisia annua L. (Qinghao) possesses anticancer properties. The underlying mechanisms of...
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Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1
BackgroundExpression of drug-metabolizing enzymes and drug transporters in liver is mainly regulated by a system of nuclear receptors. The aim of the...
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Proteomic analysis of breast cancer tissues to identify biomarker candidates by gel-assisted digestion and label-free quantification methods using LC-MS/MS
This study presents a proteomic method that differentiates between matched normal and breast tumor tissues from ductal carcinoma in situ (DCIS) and...
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Ethanol and nitric oxide modulate expression of glucocorticoid receptor in the rat adrenal cortex
BackgroundThis study was performed to investigate expression and distribution of glucocorticoid receptor (GR) in the rat adrenal cortex, acute effect...
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Antirheumatika und Antiphlogistika
In der Therapie rheumatischer Erkrankungen einschließlich degenerativer Veränderungen werden vorzugsweise nichtsteroidale Antiphlogistika eingesetzt...
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Oncogenic challenges in stem cells and the link to cancer initiation
Adult stem cells, which are characterized by self-renewal and multi-potency, are classified as specialized cell types, responsible for the...