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Feasibility of ultra-high-speed acquisition in xSPECT bone algorithm: a phantom study with advanced bone SPECT-specific phantom
ObjectiveAlthough xSPECT Bone (xB) provides quantitative single-photon emission computed tomography (SPECT) high-resolution images, patients’ burden...
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Impact of metal implants on xSPECT/CT Bone reconstruction: the “shining metal artefact”
BackgroundNovel reconstruction algorithms, such as xSPECT Bone, are gaining more and more importance in Nuclear Medicine. With xSPECT Bone, the...
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Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm
BackgroundTwo novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer...
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Quantitative single photon emission computed tomography derived standardized uptake values on 99mTc-PYP scan in patients with suspected ATTR cardiac amyloidosis
Technetium-99 pyrophosphate scintigraphy (99mTc-PYP) provides qualitative and semiquantitative diagnosis of ATTR cardiac amyloidosis (ATTR-CA) using...
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Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study
IntroductionCT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect...
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Myocardial perfusion imaging with retrospective gating and integrated correction of attenuation, scatter, respiration, motion, and arrhythmia
BackgroundAbsolute quantitative myocardial perfusion SPECT requires addressing of aleatory and epistemic uncertainties in conjunction with providing...
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Accuracy comparison of various quantitative [99mTc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses
BackgroundThere is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of...
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Inter-rater and intra-rater agreement of [99mTc]-labelled NM-01, a single-domain programmed death-ligand 1 (PD-L1) antibody, using quantitative SPECT/CT in non-small cell lung cancer
BackgroundImmune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to...
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Transthyretin amyloid cardiomyopathy disease burden quantified using 99mTc-pyrophosphate SPECT/CT: volumetric parameters versus SUVmax ratio at 1 and 3 hours
BackgroundVarious parameters derived from technetium-99m pyrophosphate ( 99m Tc-PYP) single-photon emission computed tomography (SPECT) correlate with...
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The clinical value of xSPECT/CT Bone versus SPECT/CT. A prospective comparison of 200 scans
PurposeTo prospectively evaluate the clinical utility of xSPECT/CT Bone, a new reconstruction algorithm for single photon emission tomography...
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Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method
PurposeCalculation of the uncertainty of the individual time-integrated activity coefficient (TIACs) is desirable in molecular radiotherapy. However,...
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Prediction of [177Lu]Lu-DOTA-TATE therapy response using the absorbed dose estimated from [177Lu]Lu-DOTA-TATE SPECT/CT in patients with metastatic neuroendocrine tumour
BackgroundPeptide receptor radionuclide therapy (PRRT) with [ 177 Lu]Lu-DOTA-TATE has shown efficacy in patients with metastatic neuroendocrine...
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In-vivo inhibition of neutral endopeptidase 1 results in higher absorbed tumor doses of [177Lu]Lu-PP-F11N in humans: the lumed phase 0b study
BackgroundA new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to...
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Volumetric evaluation of 99mTc-pyrophosphate SPECT/CT for transthyretin cardiac amyloidosis: Methodology and correlation with cardiac functional parameters
BackgroundVolumetric evaluation of 99m Technetium-pyrophosphate ( 99m Tc-PYP) SPECT/CT is a useful method for assessing transthyretin cardiac...
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Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems
BackgroundQuantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on...
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Quantitative bone SPECT/CT: high specificity for identification of prostate cancer bone metastases
PurposeBone scintigraphy with 99m Tc-labeled diphosphonates can identify prostate cancer bone metastases with high sensitivity, but relatively low...
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Diagnostic efficacy of bone scintigraphy in transthyretin cardiac amyloidosis: an updated systematic review and Bayesian bivariate meta-analysis
PurposeRadionuclide bone scintigraphy is increasingly attracting the attention of clinicians as a tool for the specific diagnosis of transthyretin...
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ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging
BackgroundWe investigated the clinical performance of a quantitative multi-modal SPECT/CT reconstruction platform for yielding radioactivity...
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Quantitative application of dual-phase 99mTc-sestamibi SPECT/CT imaging of parathyroid lesions: identification of optimal timing in secondary hyperparathyroidism
PurposeIn this retrospective study, we compared the maximum standardized uptake values (SUVmax) of parathyroid lesions and the target-to-background...
