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Myosin-XVa Controls Both Staircase Architecture and Diameter Gradation of Stereocilia Rows in the Auditory Hair Cell Bundles
Mammalian hair cells develop their mechanosensory bundles through consecutive phases of stereocilia elongation, thickening, and retraction of...
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Types of Inheritance and Genes Associated with Familial Meniere Disease
Meniere disease (MD) is a rare disorder of the inner ear defined by sensorineural hearing loss (SNHL) associated with episodes of vertigo and...
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Molecular aetiology of ski-slope hearing loss and audiological course of cochlear implantees
PurposeA challenge for patients with ski-slope hearing loss is that hearing aids do not adequately amplify the mid-to-high frequencies necessary for...
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Visualizing Collagen Fibrils in the Cochlea’s Tectorial and Basilar Membranes Using a Fluorescently Labeled Collagen-Binding Protein Fragment
PurposeA probe that binds to unfixed collagen fibrils was used to image the shapes and fibrous properties of the TM and BM. The probe (CNA35) is...
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Gene Therapy for Congenital Hearing Loss
Purpose of ReviewThis review provides the otolaryngology community with background on the basics of gene therapy for congenital hearing loss along...
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A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
BackgroundSensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss...
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The multifaceted links between hearing loss and chronic kidney disease
Hearing loss affects nearly 1.6 billion people and is the third-leading cause of disability worldwide. Chronic kidney disease (CKD) is also a common...
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Putting the Pieces Together: the Hair Cell Transduction Complex
Identification of the components of the mechanosensory transduction complex in hair cells has been a major research interest for many auditory and...
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Meteorological extremes and their impact on tinnitus-related emergency room visits: a time-series analysis
PurposeExtreme weather events are rising due to the accelerating pace of climate change. These events impact human health and increase emergency room...
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Role of Video Head Impulse Test to Assess Noise Exposure
Noise exposure has been reported to exert numerous detrimental effects on the human population, although most research has centred around hearing...
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The Spectral Extent of Phasic Suppression of Loudness and Distortion-Product Otoacoustic Emissions by Infrasound and Low-Frequency Tones
We investigated the effect of a biasing tone close to 5, 15, or 30 Hz on the response to higher-frequency probe tones, behaviorally, and by measuring...
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Vestibular Dysfunction Among Children with Otitis Media and Effusion in a Multiracial Setting
Otitis media with effusion (OME) is a common presentation to the Otorhinolaryngology clinic. Besides hearing impairment, recent evidence shows that...
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Pure Tone Audiometry in Anemia Patients
AimAnaemia is a prevalent medical condition that impacts a significant proportion of the worldwide populace. While the cardiovascular and respiratory...
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The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea
The cochlea of the mammalian inner ear includes an active, hydromechanical amplifier thought to arise via the piezoelectric action of the outer hair...
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Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various...
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Targeted exome sequencing identified a novel USH2A mutation in a Chinese usher syndrome family: a case report
BackgroundUsher syndrome is a disease with a heterogeneous phenotype and genotype. Our purpose was to identify the gene mutation in a Chinese family...
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The effects of different vasovasostomy techniques on motility of vas deferens (vas motility following vasovasostomy)
PurposeVasovasostomy is used to correct vas deferens (VD) transections encountered during surgery or to reverse sterilization vasectomies. Achieving...
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The Origin Along the Cochlea of Otoacoustic Emissions Evoked by Mid-Frequency Tone Pips
PurposeTone-pip-evoked otoacoustic emissions (PEOAEs) are transient-evoked otoacoustic emissions (OAEs) that are hypothesized to originate from...
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Three-dimensional mouse cochlea imaging based on the modified Sca/eS using confocal microscopy
The three-dimensional stria vascularis (SV) and cochlear blood vessel structure is essential for inner ear function. Here, modified Sca/eS, a...
