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PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have...
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Development and validation of a deep learning signature for predicting lymph node metastasis in lung adenocarcinoma: comparison with radiomics signature and clinical-semantic model
ObjectiveTo develop and validate a deep learning (DL) signature for predicting lymph node (LN) metastasis in patients with lung adenocarcinoma.
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Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is extremely aggressive, is not good. A recently identified type of controlled...
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A novel pyroptosis-related gene signature exhibits distinct immune cells infiltration landscape in Wilms’ tumor
BackgroundWilms’ tumor (WT) is the most common renal tumor in childhood. Pyroptosis, a type of inflammation-characterized and immune-related...
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Novel prognostic gene signature for pancreatic ductal adenocarcinoma based on hypoxia
BackgroundCurrently, there is lack of marker to accurately assess the prognosis of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC)....
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Neural-signature methods for structured EHR prediction
Models that can effectively represent structured Electronic Healthcare Records (EHR) are central to an increasing range of applications in...
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Multi-institutional validation of a radiomics signature for identification of postoperative progression of soft tissue sarcoma
BackgroundTo develop a magnetic resonance imaging (MRI)-based radiomics signature for evaluating the risk of soft tissue sarcoma (STS) disease...
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Interpretable Radiomic Signature for Breast Microcalcification Detection and Classification
Breast microcalcifications are observed in 80% of mammograms, and a notable proportion can lead to invasive tumors. However, diagnosing...
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Prognostic Signature Constructed of Seven Ferroptosis-Related lncRNAs Predicts the Prognosis of HBV-Related HCC
BackgroundFerroptosis and lncRNAs both play crucial roles in cancers. But the roles of ferroptosis-related lncRNAs (FRLncs) in HBV-related HCC...
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Clinical and molecular analysis of cilia-associated gene signature for prognostic prediction in glioma
PurposeGlioma is a highly malignant and unfavorable cancer in the brain. Recent evidence highlights the vital role of cilia-related pathways as novel...
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A prognostic gene signature for gastric cancer and the immune infiltration-associated mechanism underlying the signature gene, PLG
BackgroundGlobally, gastric cancer (GC) is a common and lethal solid malignant tumor. Identifying the molecular signature and its functions can...
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Comprehensive analysis of T cell exhaustion related signature for predicting prognosis and immunotherapy response in HNSCC
BackgroundT cell exhaustion (TEX) signifies a condition of T cell disorder which implicate the therapeutic benefits and prognostic significance in...
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A Cellular Senescence-Related Signature Predicts Cervical Cancer Patient Outcome and Immunotherapy Sensitivity
Cervical cancer (CC) is one of the most prevalent gynecological malignancies. The rate of mortality and morbidity among patients with CC is high....
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RUNX3 pathway signature predicts clinical benefits of immune checkpoint inhibition plus tyrosine kinase inhibition in advanced renal cell carcinoma
BackgroundCheckpoint inhibitor immunotherapy plus tyrosine kinase inhibitor (IO/TKI) have been recently recommended as standard first-line therapy...
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A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
Ovarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a...
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Individualized detection of TMPRSS2-ERG fusion status in prostate cancer: a rank-based qualitative transcriptome signature
BackgroundTMPRSS2-ERG (T2E) fusion is highly related to aggressive clinical features in prostate cancer (PC), which guides individual therapy....
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Radiomics signature for dynamic changes of tumor-infiltrating CD8+ T cells and macrophages in cervical cancer during chemoradiotherapy
BackgroundOur previous study suggests that tumor CD8+ T cells and macrophages (defined as CD68+ cells) infiltration underwent dynamic and...
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A gene signature can predict risk of MGUS progressing to multiple myeloma
Multiple myeloma is preceded by monoclonal gammopathy of undetermined significance (MGUS). Serum markers are currently used to stratify MGUS patients...
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Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma
BackgroundCancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).
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Molecular map** of a core transcriptional signature of microglia-specific genes in schizophrenia
Besides playing a central role in neuroinflammation, microglia regulate synaptic development and is involved in plasticity. Converging lines of...
