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Oxidized phospholipids in cardiovascular disease
Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic inflammation. OxPLs are present in atherosclerotic lesions and...
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CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid
Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and...
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Increased oxidative stress is associated with hyperandrogenemia in polycystic ovary syndrome evidenced by oxidized lipoproteins stimulating rat ovarian androgen synthesis in vitro
PurposeTo determine the relationship between serum total testosterone (TT) levels and oxidative stress indices in patients with polycystic ovary...
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Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker
BackgroundOxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD), prompting the exploration of antioxidants as a...
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Glycemic variability leads to higher levels of auto-oxidized oxysterol species in patients with type 1 diabetes mellitus
PurposeHyperglycemia and glycemic variability (GV) are associated with oxidative stress in patients with diabetes mellitus (DM). Oxysterol species,...
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Hypothyroidism, lipids, and lipidomics
PurposeHypothyroidism is a relatively common endocrine disorder and is well documented to be associated with lipid abnormalities.
Methods ...
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Lipids in cancer: a global view of the contribution of lipid pathways to metastatic formation and treatment resistance
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor...
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Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-κB pathway
BackgroundCircular RNAs (circRNAs) have shown important regulatory roles in cardiovascular diseases, including atherosclerosis (AS). However, the...
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Lipids as potential mediators linking body mass index to diabetes: evidence from a mediation analysis based on the NAGALA cohort
BackgroundBody mass index (BMI) and lipid disorders are both known to be strongly associated with the development of diabetes, however, the indirect...
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ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
BackgroundAsialoglycoprotein receptor 1 (ASGR1), primarily expressed on hepatocytes, promotes the clearance and the degradation of glycoproteins,...
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Impact of Lipids and Vascular Damage on Early Atherosclerosis in Adolescents with Parental Premature Coronary Artery Disease
AimTo assess the relationship of cardiovascular risk factors (CRFs) with carotid intima media thickness (IMT) in adolescents with a parental history...
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The effect of different intravenous lipids on free bilirubin levels in premature infants
BackgroundIntravenous lipid emulsions are commonly used as a part of parenteral nutrition in premature infants. The potential bilirubin-displacing...
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Circ_0003204 knockdown protects endothelial cells against oxidized low-density lipoprotein-induced injuries by targeting the miR-491-5p-ICAM1 pathway
Emerging evidence indicates that circular RNA (circRNA) is implicated in the development of atherosclerosis (AS). This study investigated the effect...
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The effect of hepatitis C virologic clearance on cardiovascular disease biomarker lipoprotein-associated phospholipase A2 and its relation to serum lipids
BackgroundChronic hepatitis C virus (HCV) infection has been linked to cardiovascular disease (CVD). However, CVD risk prediction in chronic...
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Effects of Pitavastatin on Lipoprotein Subfractions and Oxidized Low-density Lipoprotein in Patients with Atherosclerosis
It has been demonstrated that pitavastatin can significantly reduce low-density lipoprotein (LDL) cholesterol (LDL-C), but its impact on lipoprotein...
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Reduced oxidized LDL in T2D plaques is associated with a greater statin usage but not with future cardiovascular events
BackgroundType 2 diabetes (T2D) patients are at a greater risk of cardiovascular events due to aggravated atherosclerosis. Oxidized LDL (oxLDL) has...
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Effects of disease activity on lipoprotein levels in patients with early arthritis: can oxidized LDL cholesterol explain the lipid paradox theory?
BackgroundAn increased risk of cardiovascular (CV) complications has been described in patients with rheumatoid arthritis (RA). It is the result of...
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The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study
BackgroundImmune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by increased platelet destruction and impaired...
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Extracorporeal apheresis therapy for Alzheimer disease—targeting lipids, stress, and inflammation
Current therapeutic approaches to Alzheimer disease (AD) remain disappointing and, hence, there is an urgent need for effective treatments. Here, we...
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CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
BackgroundIt is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease (COPD) induced...
