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Group 3 innate lymphoid cells in intestinal health and disease
The gastrointestinal tract is an immunologically rich organ, containing complex cell networks and dense lymphoid structures that safeguard this large...
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The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells
BackgroundFormyl peptide receptor 2 (Fpr2) plays a crucial role in colon homeostasis and microbiota balance. Commensal E. coli is known to promote...
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Regulatory T cells in skin regeneration and wound healing
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal...
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The mechanism of intestinal stem cells differentiation after ischemia–reperfusion injury in a rat model
PurposeNotch and Wnt/β-catenin signaling are responsible for regulation of intestinal stem cells (ISCs) proliferation and differentiation. The...
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Gastric intestinal metaplasia: progress and remaining challenges
Most gastric cancers arise in the setting of chronic inflammation which alters gland organization, such that acid-pum** parietal cells are lost,...
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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration
Somatic stem cells have been obtained from solid organs and tissues, including the bone marrow, placenta, corneal stroma, periosteum, adipose tissue,...
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Remote ischemic conditioning avoids the development of intestinal damage after ischemia reperfusion by reducing intestinal inflammation and increasing intestinal regeneration
Aim of the studyMidgut volvulus is a potentially life-threatening condition which is based on intestinal ischemia and reperfusion (I/R) injury....
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Macrophages in intestinal homeostasis and inflammatory bowel disease
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be drivers of inflammation in the context of inflammatory...
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Inflammation accelerating intestinal fibrosis: from mechanism to clinic
Intestinal fibrosis is a prevalent complication of IBD that that can frequently be triggered by prolonged inflammation. Fibrosis in the gut can cause...
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Immunometabolic rewiring of tubular epithelial cells in kidney disease
Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response to acute and chronic injury. To adequately respond to...
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Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
The “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial...
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Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis
The latest guideline about ulcerative colitis (UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target...
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Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
The "epithelial barrier hypothesis" proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial...
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Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review
The intestine is the largest interface between the internal body and the external environment. The intestinal barrier is a dynamic system influenced...
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Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity
BackgroundColorectal cancer (CRC) is one of the most prevalent diagnosed malignancies and one of the leading causes of cancer-related deaths...
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Gut-derived immune cells and the gut-lung axis in ARDS
The gut serves as a vital immunological organ orchestrating immune responses and influencing distant mucosal sites, notably the respiratory mucosa....
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Ischemic stroke and intestinal flora: an insight into brain–gut axis
Stroke is a type of cerebrovascular disease that significantly endangers human health and lowers quality of life. This understandably places a heavy...
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Pasteurella multocida activates Rassf1-Hippo-Yap pathway to induce pulmonary epithelial apoptosis
Pasteurella multocida is an opportunistic zoonotic pathogen that primarily causes fatal respiratory diseases, such as pneumonia and respiratory...
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Decellularized extracellular matrix mediates tissue construction and regeneration
Contributing to organ formation and tissue regeneration, extracellular matrix (ECM) constituents provide tissue with three-dimensional (3D)...
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Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids
BackgroundGegen Qinlian decoction (GQD) is a classic prescription for treating ulcerative colitis (UC) in traditional Chinese medicine. However, the...
