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Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma
The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis and response to stress. Adverse childhood experience...
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Molecular and functional map** of the neuroendocrine hypothalamus: a new era begins
BackgroundRecent advances in neuroscience tools for single-cell molecular profiling of brain neurons have revealed an enormous spectrum of neuronal...
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IFN-γ differential expression in the hypothalamus-pituitary-ovary axis of thyroidectomized rats
IFN-γ is critical for both thyroid and ovarian function, while thyroxine, secreted from the thyroid gland, regulates the ovarian function via the...
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Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level
PurposeAs reported in patients treated for androgenetic alopecia with finasteride (i.e., a blocker of the enzyme 5 alpha-reductase) and in an animal...
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The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis
BackgroundThe hypothalamus plays a central role in the pathophysiology of migraine and is considered to be the “migraine generator.” It participates...
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Fetal origins of obesity: a novel pathway of regulating appetite neurons in the hypothalamus of growth-restricted rat offspring
PurposeFetal growth restriction causes a series of sequelae, some of which, such as hyperphagia, reduced satiety and postnatal obesity, are believed...
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Effects of preventative moxibustion at Shenque (CV8) and Guanyuan (CV4) on BDNF-TrkB pathway in the spinal dorsal horn and hypothalamus in rats with dysmenorrhea
ObjectiveTo observe the effects of preventative moxibustion on analgesia, substance P (SP), prostaglandin (PG) F 2α and PGE 2 in rats with...
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Neural network map** of gelastic behavior in children with hypothalamus hamartoma
BackgroundHypothalamus hamartomas (HHs) are rare, congenital, tumor-like, and nonprogressive malformations resulting in drug-resistant epilepsy,...
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A procedure in mice to obtain intact pituitary-infundibulum-hypothalamus preparations: a method to evaluate the reconstruction of hypothalamohypophyseal system
PurposeThe histopathological study of brain tissue is a common method in neuroscience. However, efficient procedures to preserve the intact...
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Pediatric craniopharyngiomas: magnetic resonance imaging assessment for hypothalamus-pituitary axis dysfunction and outcome prediction
BackgroundIn adamantinomatous craniopharyngiomas, tumor topographical categories, cystic component volume, and magnetic resonance signal intensity...
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Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety
Pain and anxiety comorbidities are a common health problem, but the neural mechanisms underlying comorbidity remain unclear. We propose that...
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Social isolation and aggression training lead to escalated aggression and hypothalamus-pituitary-gonad axis hyperfunction in mice
Although the participation of sex hormones and sex hormone-responsive neurons in aggressive behavior has been extensively studied, the role of other...
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The Human Hypothalamus Anatomy, Dysfunction and Disease Management
The hypothalamus is an anatomically small but functionally important part of the brain. In functional and pathophysiological terms, the hypothalamus...
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Oxytocin activity in the paraventricular and supramammillary nuclei of the hypothalamus is essential for social recognition memory in rats
Oxytocin plays an important role in modulating social recognition memory. However, the direct implication of oxytocin neurons of the paraventricular...
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Alterations of the expression levels of glucose, inflammation, and iron metabolism related miRNAs and their target genes in the hypothalamus of STZ-induced rat diabetes model
BackgroundThe hypothalamus of the central nervous system is implicated in the development of diabetes due to its glucose-sensing function....
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Alterations in the structural covariance network of the hypothalamus in patients with narcolepsy
PurposeThe hypothalamus plays a pivotal role in the pathogenesis of narcolepsy. This study aimed to evaluate the differences in the structural...
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Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair
Chronic stress-induced anxiodepression is a common health problem, however its potential neurocircuitry mechanism remains unclear. We used...
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Disordered hypothalamus-pituitary-ovary axis in heterotopic extraovarian sex cord-stromal proliferation: a case report of fallopian tube serous adenofibroma
BackgroundFallopian tube serous adenofibromas are uncommon tumors of the female genital tract, only dozens of cases have ever been reported. Earlier...
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Nucleus of the solitary tract A2 neurons control feeding behaviors via projections to the paraventricular hypothalamus
Hindbrain NTS neurons are highly attuned to internal physiological and external environmental factors that contribute to the control of food intake...
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Electroacupuncture pretreatment mediates sympathetic nerves to alleviate myocardial ischemia–reperfusion injury via CRH neurons in the paraventricular nucleus of the hypothalamus
BackgroundMyocardial ischemia–reperfusion can further exacerbate myocardial injury and increase the risk of death. Our previous research found that...
