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Benchmarking brain organoid recapitulation of fetal corticogenesis
Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in...
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Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain
BackgroundElevated maternal psychological distress during pregnancy is linked to adverse outcomes in offspring. The potential effects of intensified...
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Development of a Generic Fetal Physiologically Based Pharmacokinetic Model and Prediction of Human Maternal and Fetal Organ Concentrations of Cefuroxime
Background and ObjectivePhysiologically based pharmacokinetic (PBPK) models for pregnant women have recently been successfully used to predict...
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Fetal hemodynamic changes and mitochondrial dysfunction in myocardium and brain tissues in response to anemia: a lesson from hemoglobin Bart’s disease
ObjectiveWhether or not the effects of anemia in the early phase, while the fetuses attempts to increase cardiac output to meet oxygen requirement in...
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Artificial intelligence applications of fetal brain and cardiac MRI
Fetal magnetic resonance imaging (MRI) has become an appealing technology adjunct to ultrasound in the detection of fetal additional abnormalities,...
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Unique model of chronic hypoxia in fetal lambs demonstrates abnormal contrast-enhanced ultrasound brain perfusion
BackgroundChildren with congenital heart disease (CHD) demonstrate long-term neurodevelopmental impairments. We investigated contrast-enhanced...
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MR insights into fetal brain development: what is normal and what is not
Fetal brain development is a complex, rapid, and multi-dimensional process that can be documented with MRI. In the second and third trimesters, there...
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Expression of the endocannabinoid system and response to cannabinoid components by the human fetal testis
BackgroundCannabis consumption by pregnant women continues to increase worldwide, raising concerns about adverse effects on fetal growth and...
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Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience
BackgroundThis study aimed to assess the feasibility of postmortem ultra-high-field magnetic resonance imaging (UHF-MRI) to study fetal...
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Cerebral fractional tissue oxygen extraction (cFTOE) during immediate fetal-to-neonatal transition: a systematic qualitative review of the literature
Cerebral monitoring during immediate fetal-to-neonatal transition is of increasing interest. The cerebral fractional tissue oxygen extraction (cFTOE)...
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T1-weighted fast fluid-attenuated inversion-recovery sequence (T1-FFLAIR) enables the visualization and quantification of fetal brain myelination in utero
ObjectivesTo investigate the advantage of T1-weighted fast fluid-attenuated inversion-recovery MRI sequence without (T1-FFLAIR) and with compressed...
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Pituitary crosstalk with bone, adipose tissue and brain
Traditional textbook physiology has ascribed unitary functions to hormones from the anterior and posterior pituitary gland, mainly in the regulation...
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Maternal Uterine Artery Adenoviral Vascular Endothelial Growth Factor (Ad.VEGF-A165) Gene Therapy Normalises Fetal Brain Growth and Microglial Activation in Nutrient Restricted Pregnant Guinea Pigs
Fetal growth restriction (FGR) is associated with uteroplacental insufficiency, and neurodevelopmental and structural brain deficits in the infant....
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Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)
PurposeExploring synaptic density changes during brain growth is crucial to understanding brain development. Previous studies in nonhuman primates...
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Differentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence
BackgroundEarly iron deficiency (ID) is a common risk factor for poorer neurodevelopment, limiting children’s potential and contributing to global...
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Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex
Neocortex is the evolutionarily newest region in the brain, and is a structure with diversified size and morphology among mammalian species. Humans...
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Fetal MRI radiomics: non-invasive and reproducible quantification of human lung maturity
ObjectivesTo assess the reproducibility of radiomics features extracted from the develo** lung in repeated in-vivo fetal MRI acquisitions.
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Maternal PUFAs, Placental Epigenetics, and Their Relevance to Fetal Growth and Brain Development
Dietary polyunsaturated fatty acids (PUFAs), especially omega-3 (n-3) and n-6 long-chain (LC) PUFAs, are indispensable for the fetus’ brain supplied...
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The fetal brain: migration and gyration anomalies — pre- and postnatal correlations
The cerebral cortex represents a laminar structure of precisely spatially organized neurons in horizontal layers and vertical columns. Neurogenesis,...
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Fetal brain tissue characterization at 1.5 T using STrategically Acquired Gradient Echo (STAGE) imaging
ObjectivesTo estimate human fetal brain MRI tissue properties including apparent T 1 (T 1app ) and apparent proton density (PD app ) by using a rapid...
