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High intensity interval training as a novel treatment for impaired awareness of hypoglycaemia in people with type 1 diabetes (HIT4HYPOS): a randomised parallel-group study
Aims/hypothesisImpaired awareness of hypoglycaemia (IAH) in type 1 diabetes may develop through a process referred to as habituation. Consistent with...
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The impact of prior exposure to hypoglycaemia on the inflammatory response to a subsequent hypoglycaemic episode
BackgroundHypoglycaemia has been shown to induce a systemic pro-inflammatory response, which may be driven, in part, by the adrenaline response....
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Hypoglycaemia in type 1 diabetes mellitus: risks and practical prevention strategies
Hypoglycaemia, which occurs when blood levels of glucose fall below what is considered a normal range, is a well-known complication of insulin...
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Hypoglycaemia frequency and physiological response after double or triple doses of once-weekly insulin icodec vs once-daily insulin glargine U100 in type 2 diabetes: a randomised crossover trial
Aims/hypothesisThis study compared the frequency of hypoglycaemia, time to hypoglycaemia and recovery from hypoglycaemia after double or triple doses...
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Pen-administered low-dose dasiglucagon vs usual care for prevention and treatment of non-severe hypoglycaemia in people with type 1 diabetes during free-living conditions: a Phase II, randomised, open-label, two-period crossover trial
Aims/hypothesisConsumption of excess carbohydrates to manage hypoglycaemia can lead to rebound hyperglycaemia and promote weight gain. The objective...
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Effects of postprandial exercise on blood glucose levels in adults with type 1 diabetes: a review
People with type 1 diabetes experience challenges in managing blood glucose around exercise. Previous studies have examined glycaemic responses to...
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Consequences of recurrent hypoglycaemia on brain function in diabetes
The discovery of insulin and its subsequent mass manufacture transformed the lives of people with type 1 and 2 diabetes. Insulin, however, was a drug...
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Minimising hypoglycaemia in the real world: the challenge of insulin
Insulin therapy has been a life saver for people with type 1 diabetes and has been an essential tool in the therapy of people with...
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Non-invasive and minimally invasive glucose monitoring devices: a systematic review and meta-analysis on diagnostic accuracy of hypoglycaemia detection
BackgroundThe use of minimally and non-invasive monitoring systems (including continuous glucose monitoring) has increased rapidly over recent years....
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No insulin degludec dose adjustment required after aerobic exercise for people with type 1 diabetes: the ADREM study
Aims/hypothesisIt is generally recommended to reduce basal insulin doses after exercise to reduce the risk of post-exercise nocturnal hypoglycaemia....
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Switching to Degludec is Associated with Reduced Hypoglycaemia, Irrespective of Definition Used or Patient Characteristics: Secondary Analysis of the ReFLeCT Prospective, Observational Study
IntroductionHypoglycaemia is a common side effect of insulin therapy; low or high glycated haemoglobin (HbA 1c ) levels, history of hypoglycaemia or...
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Incretins beyond type 2 diabetes
Incretin-based therapies, in particular glucagon-like peptide-1 (GLP-1) receptor agonists, have been evaluated in other forms of diabetes, but...
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Assessment of selected muscle damage markers and zonulin concentration after maximum-intensity exercise in men with type 1 diabetes treated with a personal insulin pump
AimExercise-induced muscle damage depends on exercise intensity and duration and on individual susceptibility. Mechanical and metabolic stress may...
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Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Although continuous glucose monitoring (CGM) devices are now considered the standard of care for people with type 1 diabetes mellitus, the uptake...
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A single-blind, randomised, crossover study to reduce hypoglycaemia risk during postprandial exercise with closed-loop insulin delivery in adults with type 1 diabetes: announced (with or without bolus reduction) vs unannounced exercise strategies
Aims/hypothesisFor individuals living with type 1 diabetes, closed-loop insulin delivery improves glycaemic control. Nonetheless, maintenance of...
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Tirzepatide: A Review in Type 2 Diabetes
Tirzepatide (Mounjaro ® ), a first-in-class dual incretin agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1...
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Ectopic insulinoma: a systematic review
Knowledge of ectopic insulinomas comes from single cases. We performed a systematic review through PubMed, Web of Science, Embase, eLibrary and...
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Exercise in adults with type 1 diabetes mellitus
Regular physical activity improves cardiometabolic and musculoskeletal health, helps with weight management, improves cognitive and psychosocial...
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A perspective on treating type 1 diabetes mellitus before insulin is needed
Type 1 diabetes mellitus (T1DM) is a progressive autoimmune disease that starts long before a clinical diagnosis is made. The American Diabetes...
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A randomised controlled study of high intensity exercise as a dishabituating stimulus to improve hypoglycaemia awareness in people with type 1 diabetes: a proof-of-concept study
Aims/hypothesisApproximately 25% of people with type 1 diabetes have suppressed counterregulatory hormonal and symptomatic responses to...
