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Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts
PurposeThis study is to develop a new protocol that combines the use of epigenetic cues and mechanical stimuli to assemble 3D spherical structures,...
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Peripheral nerve regeneration following scaffold-free conduit transplant of autologous dermal fibroblasts: a non-randomised safety and feasibility trial
BackgroundThe use of Bio 3D nerve conduits is a promising approach for peripheral nerve reconstruction. This study aimed to assess their safety in...
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Aryl Hydrocarbon Receptor in Human Dermal Fibroblasts in the Aging Process
AbstractThe goal of this work was to examine the content of aryl hydrocarbon receptor in human dermal fibroblasts from development until deep aging...
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AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts
AbstractUltraviolet (UV) radiation is one of the main environmental factors leading to oxidative stress and accelerated skin aging. AEDG peptide, a...
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Dermal Regeneration Template: Reconstruction in Oral Cancer Defects
BackgroundPost ablative oral mucosal defect resulting from the removal of tumors can be treated with various techniques.
PurposeIn this paper, we...
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Dysregulation of extracellular matrix and Lysyl Oxidase in Ehlers-Danlos syndrome type IV skin fibroblasts
BackgroundEhlers-Danlos syndrome Type IV (aka Vascular Ehlers Danlos, or vEDS) is a dominantly inherited mutation in the Collagen 3A1 gene ( COL3A1 )....
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Norepinephrine influences the circadian clock in human dermal fibroblasts from study participants with a diagnosis of attention-deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is characterized by changes to the circadian process. Many medications used to treat the condition,...
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Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts
ObjectivesSystemic sclerosis (SSc) is characterised by tissue fibrosis of the major organs of the body including the skin, lungs and heart. We have...
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Effectiveness and safety of dermal matrix used for diabetic foot ulcer: a systematic review and meta-analysis of randomized controlled trials
BackgroundDiabetic foot ulcers (DFUs) have become a global health concern, which can lead to diabetic foot infection (DFI), lower leg amputation, and...
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Integra® and Matriderm® dermal substitute: could personal medical history and lesion characteristics influence corrective surgery adverse outcome?
BackgroundIn literature, there are no guidelines to identify which dermal matrix should be chosen and should be used in different cases. The aim of...
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Viability, Distribution and Penetration of Human Gingival Fibroblasts into Three Types of Acellular Dermal Matrix Membranes
ObjectiveThis study aimed to assess the viability, distribution and penetration of human gingival fibroblasts (HGFs) into three types of acellular...
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DYT-THAP1: exploring gene expression in fibroblasts for potential biomarker discovery
Dystonia due to pathogenic variants in the THAP1 gene (DYT-THAP1) shows variable expressivity and reduced penetrance of ~ 50%. Since THAP1 encodes a...
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A preliminary study on the impact of nutrient stress induction on drug cytotoxicity in glioblastoma cells and fibroblasts
BackgroundNutrient stress (NS), one of the hallmarks of the tumour microenvironment, can render cancer cells tolerant to cytotoxicity. Fibroblasts,...
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In Vivo Efficacy of an Injectable Human Acellular Dermal Matrix
BackgroundHuman acellular dermal matrix (hADM) has found applications in a variety of settings, particularly in breast surgery. The most common hADM...
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Basic and clinical study of the effect of exogenous hyaluronic acid on the quality of acellular dermal matrix combined with thin intermediate split thickness skin graft
BackgroundTo promote wound recovery in the recipient region, we studied the impact of exogenous hyaluronic acid (HA) on acellular dermal matrix (ADM)...
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MyD88 dimerization inhibitor ST2825 targets the aggressiveness of synovial fibroblasts in rheumatoid arthritis patients
BackgroundDimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate...
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Evaluation of the use of an acellular dermal matrix produced in a tissue bank with and without skin autografts in burn patients: a comparative study in a Colombian population
IntroductionThe dermal matrices (DM) represent a crucial advancement in plastic and reconstructive surgery by improving functional and aesthetic...
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Atomoxetine and circadian gene expression in human dermal fibroblasts from study participants with a diagnosis of attention-deficit hyperactivity disorder
Atomoxetine (ATO) is a second line medication for attention-deficit hyperactivity disorder (ADHD). We proposed that part of the therapeutic profile...
