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Magnetic Resonance Imaging-Negative Cerebral Amyloid Angiopathy: Cerebrospinal Fluid Amyloid-β42 over Amyloid Positron Emission Tomography
BackgroundCerebral amyloid angiopathy (CAA) pathology is becoming increasingly important in Alzheimer’s disease (AD) because of its potential link to...
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Improving diagnostic precision in amyloid brain PET imaging through data-driven motion correction
BackgroundHead motion during brain positron emission tomography (PET)/computed tomography (CT) imaging degrades image quality, resulting in reduced...
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Initial Experiences with Amyloid-Related Imaging Abnormalities in Patients Receiving Aducanumab Following Accelerated Approval
Aducanumab is the first FDA-approved amyloid-lowering immunotherapy for Alzheimer’s disease. There is little real-world data to guide management of...
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Amyloid-Related Imaging Abnormalities and Other MRI Findings in a Cognitively Unimpaired Population With and Without Cerebral Amyloid
BackgroundScreening data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) and Longitudinal Evaluation of Amyloid Risk and...
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Deep-learning prediction of amyloid deposition from early-phase amyloid positron emission tomography imaging
ObjectiveWhile the use of biomarkers for the detection of early and preclinical Alzheimer's Disease has become essential, the need to wait for over...
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Estimation of brain amyloid accumulation using deep learning in clinical [11C]PiB PET imaging
IntroductionEstimation of brain amyloid accumulation is valuable for evaluation of patients with cognitive impairment in both research and clinical...
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PET imaging for the evaluation of cerebral amyloid angiopathy: a systematic review
PurposeIn the last years, the role of PET imaging in the assessment of cerebral amyloid angiopathy (CAA) is emerging. In this setting, some tracers...
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Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer’s disease
PurposeDespite the revealed role of immunological dysfunctions in the development and progression of Alzheimer’s disease (AD) through animal and...
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Anti-amyloid Antibody Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a progressive neurodegenerative disorder that is extremely...
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Detection and Management of Amyloid-Related Imaging Abnormalities in Patients with Alzheimer’s Disease Treated with Anti-Amyloid Beta Therapy
Amyloid-related imaging abnormalities (ARIA) are adverse events reported in Alzheimer’s disease trials of anti-amyloid beta (Aβ) therapies. This...
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Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity
Various plasma biomarkers for amyloid-β (Aβ) have shown high predictability of amyloid PET positivity. However, the characteristics of discordance...
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Plasma Oligomer β-Amyloid and White Matter Microstructural Integrity in Cognitively Normal Older Adults According to Cerebral Amyloid Deposition
BackgroundMultimer detection system-oligomeric amyloid-β (MDS-OAβ) measure plasma OAβ level, which is associated with earlier Alzheimer’s disease...
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Amyloid-PET/CT – Überblick und Fallbeispiele
Amyloid positron emission tomography/computed tomography (PET/CT) is a helpful aid in imaging pathological cerebral amyloid deposits and is a proven...
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Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid
BackgroundLate gadolinium enhancement (LGE) is a valuable part of cardiac magnetic resonance imaging (CMR). In particular, inversion-recovery imaging...
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Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
IntroductionNon-invasive diffusion-weighted imaging (DWI) to assess brain microstructural changes via cortical mean diffusivity (cMD) has been shown...
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Phantom and clinical evaluation of the Bayesian penalised likelihood reconstruction algorithm Q.Clear without PSF correction in amyloid PET images
PurposeBayesian penalised likelihood (BPL) reconstruction, which incorporates point-spread-function (PSF) correction, provides higher signal-to-noise...
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Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
A prevalent view in treating age-dependent disorders including Alzheimer’s disease (AD) is that the underlying amyloid plaque pathology must be...
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Incidental scan findings in cardiac amyloid scintigraphy
When interpreting amyloid scintigraphy the nuclear cardiology physician should be aware of incidental image findings that may interfere with scan...
