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Therapeutic Strategies in BRAF V600 Wild-Type Cutaneous Melanoma
There have been many recent advances in melanoma therapy. While 50% of melanomas have a BRAF mutation and are a target for BRAF inhibitors, the...
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[18F]FDG PET-MR characterization of aortitis in the IL1rn−/− mouse model of giant-cell arteritis
BackgroundMetabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical...
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Wild-Type Gastrointestinal Stromal Tumors—Molecular Features, Frequency, and Consequences Among the Indian Population
Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase...
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SARS-CoV-2 Surveillance of Wild Mice and Rats in North American Cities
From July 2020 to June 2021, 248 wild house mice ( Mus musculus ), deer mice ( Peromyscus maniculatus ), brown rats ( Rattus norvegicus ), and black rats ( R...
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Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP
The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this...
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Cortical spreading depression can be triggered by sensory stimulation in primed wild type mouse brain: a mechanistic insight to migraine aura generation
BackgroundUnlike the spontaneously appearing aura in migraineurs, experimentally, cortical spreading depression (CSD), the neurophysiological...
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Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos
PurposeUnpredictable genetic modifications and chromosomal aberrations following CRISPR/Cas9 administration hamper the efficacy of germline editing....
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A Novel Near-Infrared Fluorescence Probe THK-565 Enables In Vivo Detection of Amyloid Deposits in Alzheimer’s Disease Mouse Model
PurposeNoninvasive imaging of protein aggregates in the brain is critical for the early diagnosis, disease monitoring, and evaluation of the...
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Feedback activation of EGFR/wild-type RAS signaling axis limits KRASG12D inhibitor efficacy in KRASG12D-mutated colorectal cancer
Colorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most deadly cancer worldwide. Mutational activation of KRAS G12D ...
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Specialized pro-resolution mediators in the bladder: effects of resolvin E1 on diabetic bladder dysfunction in the type 1 diabetic male Akita mouse model
BackgroundOne of the most common, but least studied, diabetic complication is diabetic bladder dysfunction. Current therapies include glucose control...
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Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
Brain tumors actively reprogram their cellular metabolism to survive and proliferate, thus offering potential therapeutic opportunities. Over the...
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CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox -/- mouse...
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Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer’s disease
Meta-analysis of genome-wide association study data has implicated PDE4B in the pathogenesis of Alzheimer’s disease (AD), the leading cause of senile...
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Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism
BackgroundMany children and young people with autism spectrum disorder (ASD) display touch defensiveness or avoidance (hypersensitivity), or engage...
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A mutation in the ZNF687 gene that is responsible for the severe form of Paget’s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model
Paget’s disease (PDB) is a late-onset bone remodeling disorder with a broad spectrum of symptoms and complications. One of the most aggressive forms...
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Loss of PMFBP1 Disturbs Mouse Spermatogenesis by Downregulating HDAC3 Expression
PurposePolyamine modulating factor 1 binding protein (PMFBP1) acts as a scaffold protein for the maintenance of sperm structure. The aim of this...
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TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer
The Tripartite motif-containing 28 (TRIM28) transcriptional cofactor is significantly upregulated in high-grade and metastatic prostate cancers. To...
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LACC1 regulates changes in the intestinal flora in a mouse model of inflammatory bowel disease
BackgroundThe aim of this study was to explore the mechanism whereby LACC1 regulates the intestinal flora in a mouse model of inflammatory bowel...
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MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes
BackgroundCardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated...
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Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway
BackgroundEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with...
