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Upstream Determinants of Overweight and Obesity in Europe
Purpose of ReviewTo review the upstream determinants of overweight and obesity in Europe, including food and built environments, and political,...
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Moving upstream: healthcare partnerships addressing social determinants of health through community wealth building
BackgroundHealthcare-based interventions addressing social needs such as food and housing generally fail to impact the upstream wealth and power...
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Upstream anticoagulation in patients with ST-segment elevation myocardial infarction: a systematic review and meta-analysis
Background and aimParenteral anticoagulation is recommended for all patients presenting with ST-segment elevation myocardial infarction (STEMI)...
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Associations between atherosclerotic luminal stenosis in the distal internal carotid artery and diffuse wall thickening in its upstream segment
ObjectivesSignificant atherosclerotic stenosis or occlusion in the distal internal carotid artery (ICA) may induce diffuse wall thickening (DWT) in...
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DHAV 3CD targets IRF7 and RIG-I proteins to block the type I interferon upstream signaling pathway
Duck hepatitis A virus type 1 (DHAV-1) is an acute, highly lethal infectious agent that infects ducklings and causes up to 95% mortality in ducklings...
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A systematic proteomic profiling and pathway analysis of protein biomarkers in diabetic retinopathy with subsequent validation of the IL-6 upstream regulator
PurposeDiabetic retinopathy (DR) is a leading cause of irreversible blindness worldwide. Identifying risk factors associated with DR development and...
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Circulating autoantibodies to alpha-enolase (ENO1) and far upstream element-binding protein 1 (FUBP1) are negative prognostic factors for pancreatic cancer patient survival
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis due to a lack of early diagnostic markers and effective therapy. In PDA patients, the...
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Paid Family Leave: An Upstream Intervention to Prevent Family Violence
PurposeFamily violence imposes tremendous costs on victims and society. Rarely are policies focused on the primary prevention of family violence....
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Circulating biomarkers of upstream kynurenine pathway and brain-derived neurotropic factor in the diagnosis of type 2 and gestational diabetes mellitus with depression
The kynurenine pathway (KP) is the main catabolic pathway for the essential amino acid tryptophan (TRP). The imbalance between beneficial and harmful...
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Salutogenic Healthy Ageing Programme Embracement (SHAPE)- an upstream health resource intervention for older adults living alone and with their spouses only: complex intervention development and pilot randomized controlled trial
BackgroundIn view of age-related health concerns and resource vulnerabilities challenging older adults to age in place, upstream health resource...
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Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases
Neuronal intranuclear inclusion disease (NIID) is neurodegenerative disease characterized by widespread inclusions. Despite the identification of GGC...
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Should We Be Using Upstream Beta-Blocker Therapy for Acute Myocardial Infarction?
Purpose of ReviewControversy exists whether beta-blockers should be given before primary percutaneous coronary intervention (PCI) or to defer their...
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Surgery scheduling heuristic considering OR downstream and upstream facilities and resources
BackgroundSurgical theater (ST) operations planning is a key subject in the healthcare management literature, particularly the scheduling of...
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Moving Diabetes Upstream: the Social Determinants of Diabetes Management and Control Among Immigrants in the US
Purpose of ReviewRelative to the US-born population, immigrants are less likely to successfully manage and control their diabetes, leading to a host...
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The joint effect of PPARG upstream genetic variation in association with long-term persistent obesity: Tehran cardio-metabolic genetic study (TCGS)
PurposeThis study is the first study that aims to assess the association between SNPs located at the PPARG gene with long term persistent obesity....
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The global diet and activity research (GDAR) network: a global public health partnership to address upstream NCD risk factors in urban low and middle-income contexts
BackgroundNon-communicable diseases (NCDs) are the leading cause of death globally. While upstream approaches to tackle NCD risk factors of poor...
