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A possible case of bictegravir-associated severe unconjugated hyperbilirubinemia
BackgroundBictegravir (BIC) co-formulated with emtricitabine (FTC) and tenofovir alafenamide (TAF) is approved by Federal Food and Drug...
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Hepatic mesenchymal hamartoma masquerading as neonatal unconjugated hyperbilirubinemia: a case report
BackgroundHepatic mesenchymal hamartoma (HMH) is the second most common benign hepatic tumor in the pediatric age group. The etiology of HMH is...
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Coexistence of mutations of Gilbert’s syndrome and Crigler-Najjar syndrome in an infant with unconjugated hyperbilirubinemia—a case report
BackgroundJaundice in the newborn period is a very common entity; rare inherited causes are often forgotten. Persistent unconjugated...
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Role of transcranial Doppler in assessment of cerebral blood flow in full term neonates with extreme unconjugated hyperbilirubinemia
PurposeTo evaluate the difference in cerebral blood flow in neonates with and without extreme unconjugated hyperbilirubinemia.
Methods ...
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Gilbert or Crigler–Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity
BackgroundSeveral mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated...
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Hyperbilirubinemia and retinopathy of prematurity: a retrospective cohort study
Retinopathy of prematurity (ROP) is a vasoproliferative retinal disease in preterm infants. Oxidative stress plays a key role in the pathogenesis of...
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Effect of phototherapy on eosinophils count in neonatal hyperbilirubinemia (cross-sectional study)
BackgroundNeonatal jaundice is a common disorder in neonates. Phototherapy is associated with various side effects despite being safe. This research...
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Unconjugated bilirubin as a state marker in patients with schizophrenia in acute episode: an Egyptian study
BackgroundThere is a substantial body of evidence linking unconjugated bilirubin to schizophrenia. Most of the earlier research has found a...
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UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China
BackgroundNeonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme...
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Case Series: Hyperbilirubinemia under elexacaftor/tezacaftor/ivacaftor in the presence of Gilbert’s syndrome
Liver-related side effects are a known complication of treatment with elexacaftor/tezacaftor/ivacaftor (ETI) for cystic fibrosis (CF). Gilbert’s...
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Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population
BackgroundSevere neonatal hyperbilirubinemia could lead to kernicterus and neonatal death. This study aimed to analyze the association between single...
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A case report of unexplained persistent conjugated hyperbilirubinemia with normal liver transaminases over 23 years: remember Dubin-Johnson syndrome!
ObjectivesIn clinical practice, clinicians usually ignore the possibility of a rare genetic disease, i.e., Dubin-Johnson Syndrome (DJS), for...
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Effect of Oral Zinc Supplementation on Serum Bilirubin Levels in Term Neonates With Hyperbilirubinemia Undergoing Phototherapy: A Double-blind Randomized Controlled Trial
BackgroundEnterohepatic bilirubin circulation is one of the determinants of neonatal jaundice.
ObjectiveTo evaluate the role of oral zinc in...
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The differential value of radiomics based on traditional T1-weighted sequences in newborns with hyperbilirubinemia
BackgroundOn the basis of visual-dependent reading method, radiological recognition and assessment of neonatal hyperbilirubinemia (NH) or acute...
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“Fenofibrate as an adjuvant to phototherapy in pathological unconjugated hyperbilirubinemia in neonates: a randomized control trial.”
BackgroundDespite widespread phototherapy usage, many new-born infants remain in need of other invasive lines of therapy, such as intravenous...
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Gilbert’s Syndrome in Children with Unconjugated Hyperbilirubinemia – An Analysis of 170 Cases
There is limited literature on Gilbert’s syndrome (GS) in children with persistent unconjugated hyperbilirubinemia from Indian subcontinent. All...
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The prognostic significance of postoperative hyperbilirubinemia in cardiac surgery: systematic review and meta-analysis
BackgroundHyperbilirubinemia following cardiac surgery is a common phenomenon and is of emerging interest in prognostic factor research. This...
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Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis
BackgroundNeonatal hyperbilirubinemia is observed in most newborns, and 5–15% of neonates require phototherapy. Phototherapy is effective but often...
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Associations between UGT1A1 and SLCO1B1 polymorphisms and susceptibility to neonatal hyperbilirubinemia in Thai population
Hyperbilirubinemia is the main mechanism that causes neonatal jaundice, and genetics is one of the risk factors of hyperbilirubinemia. Therefore,...
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Management of severe hyperbilirubinemia in the cholestatic neonate: a review and an approach
A review of the literature demonstrates that severe total hyperbilirubinemia (total serum bilirubin ≥ 20 mg/dL [340 µmol/L]) in some cholestatic term...