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Correlation between vitamin D metabolites and rheumatoid arthritis with osteoporosis by ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS)
IntroductionOur aim is to study the correlation between vitamin D metabolites and osteoporosis in rheumatoid arthritis (RA) by ultra-high-performance...
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Assessment of pheniramine in alternative biological matrices by liquid chromatography tandem mass spectrometry
Pheniramine is an over-the-counter antihistamine drug. Its accessibility and low cost made it more popular among drug abusers in Pakistan. In this...
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Methyl (S)-2-(1–7 (5-fluoropentyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate (5F-MDMB-PICA) intoxication in a child with identification of two new metabolites (ultra-high-performance liquid chromatography–tandem mass spectrometry)
PurposeMethyl (S)-2-(1–7 (5-fluoropentyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate (5F-MDMA-PICA) intoxication in 1.5-year-old child was...
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Green analytical toxicology method for determination of synthetic cathinones in oral fluid samples by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry
PurposeWe developed and validated a method for quantitative analysis of ten synthetic cathinones in oral fluid (OF) samples, using microextraction by...
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Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry
BackgroundTanreqing capsules (TRQCs) and Tanreqing injections (TRQIs) are widely used in the treatment of respiratory diseases. In this study, a...
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Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography–tandem mass spectrometry
PurposeMethorphan exists in two enantiomeric forms including dextromethorphan and levomethorphan. Dextromethorphan is an over-the-counter antitussive...
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High-sensitivity method for the determination of LSD and 2-oxo-3-hydroxy-LSD in oral fluid by liquid chromatography‒tandem mass spectrometry
PurposeWe have developed and validated a high-sensitivity method to quantify lysergic acid diethylamide (LSD) and 2-oxo-3-hydroxy-LSD (OH-LSD) in...
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Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry
BackgroundDuring biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and...
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Discovery of potential biomarkers in acute kidney injury by ultra-high-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF–MS)
ObjectiveThe LC – MS/MS-based non-targeted metabolomics method was used to differentially screen serum and urine metabolites of acute kidney injury...
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Development and validation of an ultra-performance liquid chromatography–tandem mass spectrometric method for the determination of 25 psychoactive drugs in cerumen and its application to real postmortem samples
PurposeIn the present study, a method for the detection of 25 psychoactive substances in cerumen was developed and validated. This method targets...
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Liquid chromatography with tandem mass spectrometric method for determination of 425 drugs and poisons in dried blood spots and application to forensic cases
PurposeAn analytical method using liquid chromatography with tandem mass spectrometry (LC–MS/MS) was established and validated for screening 425...
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The next addiction-causing drug class 4-quinazolinone derivatives: analyses of methaqualone analogs including recently discovered 2-methoxyqualone by different modes of mass spectrometry
PurposeThe information on analytical methods for 4-quinazolinone recreational drugs, such as methaqualone, etaqualone and 2-methoxyqualone, is almost...
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Rapid detection of α-amanitin and β-amanitin in rat plasma by ultra-performance liquid chromatography–tandem mass spectrometry and its application to the toxicokinetic study of Lepiota brunneoincarnata
PurposeLepiota brunneoincarnata is a well-known poisonous mushroom and is responsible for fatal mushroom poisoning cases worldwide. α-Amanitin and...
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Simultaneous quantification of bioactive components in Chinese herbal spirits by ultra-high performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC–QQQ–MS/MS)
BackgroundThe Chinese medicinal wine made from herbal medicines became prevalent among Chinese people. The Chinese herbal spirit is composed of...
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First liquid chromatography–high resolution mass spectrometry method for the determination of cocaine on banknote dust
PurposePrevalence measures of sociological interest concerning cocaine presence on banknotes are fraught with (i) the extreme variability of its...
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Detection of IEMs by Mass Spectrometry Techniques in High-Risk Children: A Pilot Study
ObjectivesTo determine the incidence and types of inborn errors of metabolism (IEMs) in high-risk children using mass spectrometry techniques.
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Development and validation of quantitative analytical method for 50 drugs of antidepressants, benzodiazepines and opioids in oral fluid samples by liquid chromatography–tandem mass spectrometry
PurposeWe developed and validated a method for quantitative analysis of 50 psychoactive substances and metabolites (antidepressants, benzodiazepines...
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Alpha-methyltryptamine and 5-(2-methylaminopropyl)-benzofuran (5-MAPB) fatal co-intoxication: case report and review of literature
The scientific literature contains little reliable data regarding new psychoactive substances and designer drugs, making it difficult to assess toxic...
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Metabolite identification of salvianolic acid A in rat using post collision-induced dissociation energy-resolved mass spectrometry
BackgroundAs one of the most famous natural products, salvianolic acid A (SAA) is undergoing clinical trials for the treatments of angina pectoris...
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Mass Spectrometry-Based Approaches for Clinical Biomarker Discovery in Traumatic Brain Injury
Purpose of ReviewPrecision treatments to address the multifaceted pathophysiology of traumatic brain injury (TBI) are desperately needed, which has...
