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Usefulness of tissue inhibitor of metalloproteinase 1 as a predictor of sustained remission in patients with antineutrophil cytoplasmic antibody-associated vasculitis
BackgroundWe previously identified tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker of disease activity that distinguished mildly or...
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Tissue inhibitor of matrix metalloprotinase-1 and collagen type IV in HCV-associated cirrhosis and grading of esophageal varices
BackgroundEsophageal varices are abnormally dilated submucosal veins of the esophagus which develop as a result of portal hypertension due to...
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Infigratinib, a Selective Fibroblast Growth Factor Receptor Inhibitor, Suppresses Stent-Induced Tissue Hyperplasia in a Rat Esophageal Model
PurposeStent-induced tissue hyperplasia remains a challenge for the application of self-expanding metal stents in the management of esophageal...
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Urinary Insulin-Like Growth Factor-Binding Protein 7 (IGFBp7), Urinary Tissue Inhibitor of Matrix Metalloproteinase 2 (TIMP2), and Serum Transgelin as Novel Biomarkers of Kidney Injury in Multiple Myeloma
Renal dysfunction is a common complication of MM and is associated with poor prognosis, particularly when progressive. Early identification of renal...
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Matrix metalloproteinase-1 as a non-invasive biomarker to assess liver fibrosis in children with chronic liver disease
BackgroundAbnormal extracellular matrix (ECM) turnover is linked to liver fibrosis as it reflects an imbalance between repair and progressive...
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Hesperetin attenuates the expression of markers of adipose tissue fibrosis in pre-adipocytes
BackgroundExcessive extracellular matrix (ECM) deposition in adipose tissue is a hallmark of fibrosis, leading to disrupted adipose tissue...
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The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders
Excessive fat deposition in obese subjects promotes the occurrence of metabolic diseases, such as type 2 diabetes mellitus (T2DM), cardiovascular...
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Plasminogen activator inhibitor 1 and gestational diabetes: the causal relationship
Plasminogen activator inhibitor 1 (PAI-1) also known as serpin E1 or endothelial plasminogen activator inhibitor, is produced from endothelial cells...
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A cysteine proteinase inhibitor ALLN alleviates bleomycin-induced skin and lung fibrosis
BackgroundSystemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the...
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Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells
Background . Peritumoral fibroblasts are key components of the tumor microenvironment. Through remodeling of the extracellular matrix (ECM) and...
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Differences in metalloproteinases and their tissue inhibitors in the cerebrospinal fluid are associated with delirium
BackgroundThe aetiology of delirium is not known, but pre-existing cognitive impairment is a predisposing factor. Here we explore the associations...
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Anti-inflammatory effects of the prostaglandin D2/prostaglandin DP1 receptor and lipocalin-type prostaglandin D2 synthase/prostaglandin D2 pathways in bacteria-induced bovine endometrial tissue
Dairy cows often develop different degrees of endometritis after calving and this is attributed to pathogenic bacterial infections such as by Escherich...
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High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer
BackgroundAn emerging subset of oropharyngeal squamous cell carcinomas (OPSCC) is caused by HPV. HPV-positive OPSCC has a better prognosis than...
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Treatment of calcinosis cutis associated with autoimmune connective tissue diseases
Calcinosis cutis is a condition that is commonly associated with autoimmune connective tissue diseases. It is characterized by the deposition of...
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The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
BackgroundInflammation, oxidative stress and an imbalance between proteases and protease inhibitors are recognized pathophysiological features of...
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The evaluation of the MMP-2/TIMP-1 ratio in peptic ulcer and its association with refractory helicobacter pylori infection
BackgroundHelicobacter pylori ( H. pylori ) is one of the leading causes of peptic ulcers, and its treatment is a worldwide challenge. Matrix...
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Potential molecular mechanism underlying cardiac fibrosis in diabetes mellitus: a narrative review
BackgroundDiabetes mellitus (DM) is among the most common risk factors for cardiovascular disease in the world with prevalence of more than 500...
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Tissue Inhibitor of Metalloprotease-1 (TIMP-1) Regulates Adipogenesis of Adipose-derived Stem Cells (ASCs) via the Wnt Signaling Pathway in an MMP-independent Manner
Tissue inhibitor of metalloprotease-1 (TIMP-1) is a tissue inhibitor of matrix metalloproteinases (MMPs). It however exerts multiple effects on...
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Cluster analysis of extracellular matrix biomarkers predicts the development of impaired systolic function within 1 year of acute myocardial infarction
The clinical utility of combining extracellular matrix (ECM) biomarkers to predict the development of impaired systolic function following acute...
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Unraveling the complex roles of macrophages in obese adipose tissue: an overview
Macrophages, a heterogeneous population of innate immune cells, exhibit remarkable plasticity and play pivotal roles in coordinating immune responses...