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1. The future of brain circuit-targeted therapeutics

   The principle of targeting brain circuits has drawn increasing attention with the growth of brain stimulation treatments such as transcranial...

   Shan H. Siddiqi, Sanaz Khosravani, ... Michael D. Fox in Neuropsychopharmacology

   Article 31 July 2023
   

2. Psoriasis in the Era of Targeted Cancer Therapeutics: A Systematic Review on De Novo and Pre-existing Psoriasis in Oncologic Patients Treated with Emerging Anti-neoplastic Agents

   New advancements in medicine have paved the way for targeted therapies and immune checkpoint inhibitors (ICIs), which have become mainstays of cancer...

   Vrinda Madan, Laura I. Ortiz-López, ... Vinod E. Nambudiri in Dermatology and Therapy

   Article Open access 22 June 2024
   

3. FGFR-targeted therapeutics: clinical activity, mechanisms of resistance and new directions

   Fibroblast growth factor (FGF) signalling via FGF receptors (FGFR1–4) orchestrates fetal development and contributes to tissue and whole-body...

   Masuko Katoh, Yohann Loriot, ... Masaru Katoh in Nature Reviews Clinical Oncology

   Article 29 February 2024
   

4. Nucleic acid therapeutics as differentiation agents for myeloid leukemias

   Differentiation therapy has proven to be a success story for patients with acute promyelocytic leukemia. However, the remaining subtypes of acute...

   Olivia Kovecses, François E. Mercier, Maureen McKeague in Leukemia

   Article Open access 29 February 2024
   

5. Fundamental concepts of protein therapeutics and spacing in oncology: an updated comprehensive review

   Current treatment regimens in cancer cases cause significant side effects and cannot effectively eradicate the advanced disease. Hence, much effort...

   Bahareh Farasati Far, Maryam Safaei, ... Mohammad Reza Naimi-Jamal in Medical Oncology

   Article 05 May 2023
   

6. Management and Novel Therapeutics for Odontogenic Tumors

   Purpose of Review

   The identification of tumor molecular markers continues to become more widespread. The application of such markers however lags the...

   Kanvar S. Panesar, Jasjit Dillon in Current Surgery Reports

   Article 07 June 2024
   

7. A Clinical Approach to Existing and Emerging Therapeutics in Neuromyelitis Optica Spectrum Disorder

   Purpose of Review

   Neuromyelitis optica spectrum disorder (NMOSD) is a rare but highly disabling disease of the central nervous system. Unlike multiple...

   Heather Y. F. Yong, Jodie M. Burton in Current Neurology and Neuroscience Reports

   Article 04 August 2023
   

8. Complement therapeutics are coming of age in rheumatology

   The complement system was described over 100 years ago, and it is well established that activation of this pathway accompanies the great majority of...

   V. Michael Holers in Nature Reviews Rheumatology

   Article 19 June 2023
   

9. Immunotherapy: The Fourth Domain in Oral Cancer Therapeutics

   Owing to high global prevalence, incidence and associated mortality, cancer of head and neck particularly oral cancer remains a cardinal domain for...

   Ruby Dwivedi, Ayushi Jain, ... Shaleen Chandra in Indian Journal of Otolaryngology and Head & Neck Surgery

   Article 10 March 2024
   

10. Integrating Digital Therapeutics With Mental Healthcare Delivery

    This overview explores digital therapeutics (DTx) for mental health and their use in clinical practice for mental health service delivery. DTx...

    Michelle Liu, Stephen M. Schueller in Journal of Health Service Psychology

    Article 01 May 2024

11. RNA Therapeutics: the Next Generation of Drugs for Cardiovascular Diseases

    Purpose of Review

    RNA therapeutics are a new and rapidly expanding class of drugs to prevent or treat a wide spectrum of diseases. We discuss the...

    Nada Bejar, Trinh T. Tat, Daniel L. Kiss in Current Atherosclerosis Reports

    Article 02 April 2022
    

12. Nanocrystals: an emerging paradigm for cancer therapeutics

    Background

    Medical fraternity are continuously pitching toward the development of novel mechanisms to combat the menace of cancer and to enhance the...

    Ayush Patel, Krishi Patel, ... Amarjitsing Rajput in Future Journal of Pharmaceutical Sciences

    Article Open access 05 January 2024
    

13. RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

    Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly...

    Wei-Wei Liu, Si-Qing Zheng, ... Hao Wang in Signal Transduction and Targeted Therapy

    Article Open access 27 March 2024
    

14. TGF-β signaling in health, disease, and therapeutics

    Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every tissue and cell type. The signal transduction of TGF-β can...

    Ziqin Deng, Tao Fan, ... Jie He in Signal Transduction and Targeted Therapy

    Article Open access 22 March 2024
    

15. Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases

    Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors (S1PRs), is a bioactive lipid essential for vascular integrity and...

    Nathalie Burg, Jane E. Salmon, Timothy Hla in Nature Reviews Rheumatology

    Article 04 May 2022
    

16. Immune checkpoint targeting antibodies hold promise for combinatorial cancer therapeutics

    Through improving the immune system's ability to recognize and combat tumor cells as well as its receptivity to changes in the tumor...

    Ritu, Prakash Chandra, Asmita Das in Clinical and Experimental Medicine

    Article 07 October 2023
    

17. Implementation and workflow strategies for integrating digital therapeutics for alcohol use disorders into primary care: a qualitative study

    Background

    Alcohol use disorders (AUD) are prevalent and often go untreated. Patients are commonly screened for AUD in primary care, but existing...

    Jessica M. Mogk, Theresa E. Matson, ... Joseph E. Glass in Addiction Science & Clinical Practice

    Article Open access 08 May 2023

18. Burning down the house: reinventing drug discovery in psychiatry for the development of targeted therapies

    Despite advances in neuroscience, limited progress has been made in develo** new and better medications for psychiatric disorders. Available...

    Andrew H. Miller, Charles L. Raison in Molecular Psychiatry

    Article 02 December 2022
    

19. CD6-targeted antibody-drug conjugate as a new therapeutic agent for T cell lymphoma

    T cell lymphomas (TCL) are heterogeneous, aggressive, and have few available targeted therapeutics. In this study, we determined that CD6, an...

    Neetha Parameswaran, Li** Luo, ... Feng Lin in Leukemia

    Article 12 August 2023
    

20. Cross-reactivity to glutamate carboxypeptidase III causes undesired salivary gland and kidney uptake of PSMA-targeted small-molecule radionuclide therapeutics

    Purpose

    Recently, Pluvicto™ ([ ¹⁷⁷ Lu]Lu-PSMA-617), a small-molecule prostate-specific membrane antigen (PSMA) radioligand therapeutic, has been...

    Laura Lucaroni, Tony Georgiev, ... Gabriele Bassi in European Journal of Nuclear Medicine and Molecular Imaging

    Article 03 October 2022