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Novel biomarkers identified by weighted gene co-expression network analysis for atherosclerosis
BackgroundThis study aimed to screen out the potential diagnostic biomarkers for atherosclerosis (AS).
MethodsWe downloaded the gene expression...
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Identification of potential diagnostic biomarkers for tenosynovial giant cell tumour by integrating microarray and single-cell RNA sequencing data
PurposeTenosynovial giant cell tumour (TGCT) is a benign hyperplastic and inflammatory disease of the joint synovium or tendon sheaths, which may be...
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Screening and identification of potential key biomarkers for glucocorticoid-induced osteonecrosis of the femoral head
BackgroundGlucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a common disease in osteoarticular surgery, with a high disability...
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Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study
This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in...
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Identification and validation of glomerulotubular crosstalk genes mediating IgA nephropathy by integrated bioinformatics
BackgroundIgA nephropathy (IgAN), which has been reported as the most prevalent glomerulonephritis globally, is the major contributor to end-stage...
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Landscape of infiltrating immune cells and related genes in diabetic kidney disease
IntroductionDiabetic kidney disease (DKD) is one of the prominent microvascular complications of diabetes and the leading cause of end-stage renal...
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Identification of potential core genes in pseudoexfoliation using bioinformatics analysis and retrospective analysis of 84 patients with this disease
BackgroundPseudoexfoliation (XFS) is a common cause of glaucoma in nowadays. Because of XFS causing irreversible blindness secondary to glaucoma...
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Identification of key biomarkers in steroid-induced osteonecrosis of the femoral head and their correlation with immune infiltration by bioinformatics analysis
ObjectiveThis study aimed to identify key diagnostic markers and immune infiltration of (SONFH) by bioinformatics analysis.
MethodsRelated SONFH...
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Bioinformatics analysis and identification of genes and molecular pathways in steroid-induced osteonecrosis of the femoral head
BackgroundSteroid-induced osteonecrosis of the femoral head (ONFH) is a common hip joint disease and is difficult to be diagnosed early. At present,...
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IRF8 and its related molecules as potential diagnostic biomarkers or therapeutic candidates and immune cell infiltration characteristics in steroid-induced osteonecrosis of the femoral head
PurposeSteroid-induced osteonecrosis of the femoral head (SONFH) was a refractory orthopedic hip joint disease in the young and middle-aged people,...
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Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer’s disease (AD) and is a network hub...
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Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
Integrative gene network approaches enable new avenues of exploration that implicate causal genes in sporadic late-onset Alzheimer’s disease (LOAD)...
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Identification of Common and Specific Genes Involved in Mouse Models of Age-Related and Cyclophosphamide-Induced Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is an etiologically heterogeneous disorder that usually leads to poor reproductive outcomes. Does a specific or...
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Identification of diagnostic markers and immune cell infiltration characteristics in antineutrophil cytoplasmic antibody-associated vasculitis by weighted gene co-expression network analysis
BackgroundAntineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of life-threatening systemic autoimmune diseases. The aim of...
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Bioinformatics Analysis Reveals Novel Differentially Expressed Genes Between Ectopic and Eutopic Endometrium in Women with Endometriosis
BackgroundEndometriosis is one of the chronic and prevalent diseases among women. There is limited knowledge about its pathophysiology at the...
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In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy
BackgroundHuman Kidney Injury Molecule-1, also known as HAVCR-1 (Hepatitis A virus cellular receptor 1), belongs to the cell-surface protein of...
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RNA sequencing of the thalamus and rostral ventral medulla in rats with chronic orofacial pain
Diagnosing and treating chronic orofacial pain is challenging due to its complex structure and limited understanding of its causes and mechanisms. In...
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A prognostic gene signature for gastric cancer and the immune infiltration-associated mechanism underlying the signature gene, PLG
BackgroundGlobally, gastric cancer (GC) is a common and lethal solid malignant tumor. Identifying the molecular signature and its functions can...
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Gene correlation network analysis to identify regulatory factors in sciatic nerve injury
BackgroundSciatic nerve injury (SNI), which frequently occurs under the traumatic hip and hip fracture dislocation, induces serious complications...
