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Ketamine induced synaptic plasticity operates independently of long-term potentiation
Synaptic plasticity occurs via multiple mechanisms to regulate synaptic efficacy. Homeostatic and Hebbian plasticity are two such mechanisms by which...
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d-Cycloserine enhances the bidirectional range of NMDAR-dependent hippocampal synaptic plasticity
The partial N-methyl-D-aspartate receptor (NMDAR) agonist d -Cycloserine (DCS) has been evaluated for the treatment of a wide variety of psychiatric...
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Synaptic plasticity and mental health: methods, challenges and opportunities
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that allows neurons to communicate and change their connections...
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Interplay between hippocampal TACR3 and systemic testosterone in regulating anxiety-associated synaptic plasticity
Tachykinin receptor 3 (TACR3) is a member of the tachykinin receptor family and falls within the rhodopsin subfamily. As a G protein-coupled...
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Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer’s disease
Cognitive deterioration and memory decline associated with the progression of Alzheimer’s disease (AD) primarily results from synaptic failure....
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Olfactory Three-Needle Electroacupuncture Improved Synaptic Plasticity and Gut Microbiota of SAMP8 Mice by Stimulating Olfactory Nerve
ObjectiveTo investigate the effects and mechanisms of olfactory three-needle (OTN) electroacupuncture (EA) stimulation of the olfactory system on...
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The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Fear-related pathologies are among the most prevalent psychiatric conditions, having inappropriate learned fear and resistance to extinction as...
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CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory
The late 1990s were banner years in molecular neuroscience; seminal studies demonstrated that local protein synthesis, at or near synapses, was...
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Analysis of sleep deprivation-associated Homer1 gene and protein acting on synaptic plasticity by bioinformatics and animal experiments
BackgroundHomer1, an immediate early gene, is related to sleep deprivation (SD), and its protein products are involved in synaptic plasticity...
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Adaptive control of synaptic plasticity integrates micro- and macroscopic network function
Synaptic plasticity configures interactions between neurons and is therefore likely to be a primary driver of behavioral learning and development....
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Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits
ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay,...
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Improvement of synaptic plasticity and cognitive function in RASopathies—a monocentre, randomized, double-blind, parallel-group, placebo-controlled, cross-over clinical trial (SynCoRAS)
BackgroundCognitive impairment is a common medical issue in rat sarcoma (RAS) pathway disorders, so-called RASopathies, like Neurofibromatosis type 1...
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KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2
The excitatory neurotransmitter glutamate shapes learning and memory, but the underlying epigenetic mechanism of glutamate regulation in neuron...
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Enhancing GluN2A-type NMDA receptors impairs long-term synaptic plasticity and learning and memory
N-methyl-D-aspartic acid type glutamate receptors (NMDARs) play critical roles in synaptic transmission and plasticity, the dysregulation of which...
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PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine
AimsChronic migraine (CM) is a common neurological disorder with complex pathogenesis. Evidence suggests that pituitary adenylate cyclase-activating...
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Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy
PurposeTemporal lobe epilepsy (TLE) is a common, polygenic epilepsy syndrome that involves glucose hypometabolism in the epileptogenic zone. However,...
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Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory
Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory. Abnormalities in homeostatic plasticity cause severe...
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Distinct roles of astroglia and neurons in synaptic plasticity and memory
Long-term potentiation (LTP) in the hippocampus is the most studied form of synaptic plasticity. Temporal integration of synaptic inputs is essential...
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Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice
Addiction-related compulsion-like behavior can be modeled in rodents with drug self-administration (SA) despite harmful consequences. Recent studies...
