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Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1
PD-L1 is an immune checkpoint inhibitor, whose surface expression may be exploited by cancer cells to escape T cell-mediated immune recognition....
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Automated characterization of patient–ventilator interaction using surface electromyography
BackgroundCharacterizing patient–ventilator interaction in critically ill patients is time-consuming and requires trained staff to evaluate the...
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Regulation of tissue factor activity by interaction with the first PDZ domain of MAGI1
BackgroundTissue factor (TF) activity is stringently regulated through processes termed encryption. Post-translational modification of TF and its...
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Research on the interaction of astragaloside IV and calycosin in Astragalus membranaceus with HMGB1
BackgroundHigh mobility group box 1 protein (HMGB1), a lethal late inflammatory mediator, contributes to the pathogenesis of diverse inflammatory and...
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Composite-veneering of polyether-ether-ketone (PEEK): evaluating the effects of different surface modification methods on surface roughness, wettability, and bond strength
This study aimed to evaluate the effects of different surface modification methods on the surface roughness, contact angle, and bond strength of...
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Differential platelet activation through an interaction with spike proteins of different SARS-CoV-2 variants
COVID-19 disease is associated with an increased risk of thrombotic complications, which contribute to high short-term mortality. Patients with...
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Exploring sustainable forensics: silica nanoparticle powder derived from rice husk waste for aged fingermark development and the chemistry of surface interactions
BackgroundPowder-based fingermark ridge visibility enhancement is a common technique employed in crime scenes due to ease of application and...
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Unlocking the potential: laser surface modifications for titanium dental implants
The review critically evaluates the current state of studies investigating laser irradiation for modifying titanium surfaces to enhance the...
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Mechanism of action, resistance, interaction, pharmacokinetics, pharmacodynamics, and safety of fostemsavir
The Food and Drug Administration (FDA) has licensed many antiretroviral medications to treat human immunodeficiency virus type 1 (HIV-1), however,...
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Profiling of insulin and resveratrol interaction using multi-spectroscopy and molecular docking study
BackgroundResveratrol, a phenolic compound, has various medicinal properties, including anticancer, anti-diabetic, antioxidant, anti-inflammatory,...
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Notoginsenoside R1 can inhibit the interaction between FGF1 and VEGFA to retard podocyte apoptosis
BackgroundDiabetic nephropathy (DN) is a chronic condition resulting from microangiopathy in a high-glucose environment. The evaluation of vascular...
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ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface
The poor prognosis of hepatocellular carcinoma (HCC) is mainly because of its high rate of metastasis. Thus, elucidation of the molecular mechanisms...
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Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
BackgroundPulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is...
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Study on articular surface morphology of atlantoaxial lateral mass based on differential manifold
ObjectivesTo propose a surface reconstruction algorithm based on a differential manifold (a space with local Euclidean space properties), which can...
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Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers
YAP activation in cancer is linked to poor outcomes, making it an attractive therapeutic target. Previous research focused on blocking the...
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Video analysis of optic-haptic-interaction during hydrophobic acrylic intraocular lens implantation using preloaded injectors
ObjectiveTo compare the optic-haptic interaction of different hydrophobic acrylic IOLs after using six preloaded injectors.
MethodsWe reviewed the...
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Blockage of Orai1-Nucleolin interaction meditated calcium influx attenuates breast cancer cells growth
As an important second messenger, calcium (Ca 2+ ) regulates a wide variety of physiological processes. Disturbance of intracellular calcium...
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YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression
The hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial cadherin (E-cadherin) to neural cadherin (N-cadherin),...
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Optimum selection for multi-interaction events in Compton-PET hybrid reconstruction: a Monte Carlo study
In Compton PET, that has a scatterer inserted inside a PET ring, there are multi-interaction events that can be treated as both PET and Compton...
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The Role of the Ocular Surface Microbiome (OSM) in Diseases of the Anterior Segment and Ocular Surface
Purpose of ReviewIn this article, we define the ocular surface microbiome (OSM) and review the literature investigating its putative role in anterior...